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AMG8379

an Nav1.7 channel antagonist; structure in first source

Also Known As:

1-(3'-chloro-2,5'-difluoro-5-methoxy-4-biphenylyl)-N-3-isoxazolyl-2-oxo-1,2-dihydro-6-quinolinesulfonamide

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - AMG8379: 1
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - AMG8379: 1
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        AMG8379: 1

Experts

1.	Altmann, Stephen: 1 article (01/2017)
2.	Be, Xuhai: 1 article (01/2017)
3.	Berry, Virginia: 1 article (01/2017)
4.	Fremeau, Robert T: 1 article (01/2017)
5.	Ilch, Christopher P: 1 article (01/2017)
6.	Jarosh, Michael: 1 article (01/2017)
7.	Johnson, Danielle: 1 article (01/2017)
8.	Kornecook, Thomas J: 1 article (01/2017)
9.	Lee, Josie H: 1 article (01/2017)
10.	Lehto, Sonya G: 1 article (01/2017)

Related Diseases

1.	Pain (Aches) 01/01/2017 - "AMG8379 is a potent and selective NaV1.7 inhibitor that blocks sodium current in heterologous cells as well as DRG neurons, inhibits action potential firing in peripheral nerve fibers, and exhibits pharmacodynamic effects in translatable models of both itch and pain."
2.	Hyperalgesia 01/01/2017 - "AMG8379 dose-dependently inhibited intradermal histamine-induced scratching and intraplantar capsaicin-induced licking, and reversed UVB radiation skin burn-induced thermal hyperalgesia; notably, behavioral effects were not observed with AMG8380 at similar plasma exposure levels. "
3.	Burns 01/01/2017 - "AMG8379 dose-dependently inhibited intradermal histamine-induced scratching and intraplantar capsaicin-induced licking, and reversed UVB radiation skin burn-induced thermal hyperalgesia; notably, behavioral effects were not observed with AMG8380 at similar plasma exposure levels. "

Related Drugs and Biologics

1.	Sodium
2.	Histamine (Histamine Dihydrochloride)
3.	Capsaicin (Zostrix)