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HBK-15

a dual 5-HT1A and 5-HT7 antagonist; structure in first source

Also Known As:

1-((2-chloro-6-methylphenoxy)ethoxyethyl)-4-(2-methoxyphenyl)piperazine

Networked: 4 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Phenyl Ethers: 8
        HBK-15: 4
- Ethers: 242
  - Phenyl Ethers: 8
    - HBK-15: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - HBK-15: 4

Experts

1.	Pytka, Karolina: 3 articles (01/2017 - 01/2016)
2.	Waszkielewicz, Anna: 3 articles (01/2017 - 01/2016)
3.	Głuch-Lutwin, Monika: 2 articles (01/2017 - 01/2016)
4.	Jakubczyk, Magdalena: 2 articles (01/2017 - 01/2016)
5.	Kotańska, Magdalena: 2 articles (01/2017 - 01/2016)
6.	Gawlik, Katarzyna: 1 article (01/2017)
7.	Janiszewska, Paulina: 1 article (01/2017)
8.	Pawlica-Gosiewska, Dorota: 1 article (01/2017)
9.	Walczak, Maria: 1 article (01/2017)
10.	Witalis, Jadwiga: 1 article (01/2017)

Related Diseases

1.	Anxiety Disorders (Anxiety Disorder) 03/01/2023 - "This study indicates that multimodal compounds with a receptor profile similar to HBK-15 could be an attractive therapeutic option for patients with a generalized anxiety disorder. " 01/01/2016 - "Positive results of our preliminary experiments on the safety of HBK-14 and HBK-15 encourage further studies concerning their effectiveness in the treatment of depression and/or anxiety disorders."
2.	Cognitive Dysfunction 01/01/2017 - "Only HBK-15 (0.625 mg/kg) presented memory-enhancing properties and ameliorated cognitive impairments caused by scopolamine (1 mg/kg). "
3.	Body Weight (Weight, Body) 01/01/2017 - "We also evaluated the influence of HBK-15 on brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) levels in the hippocampus and prefrontal cortex, as well as body weight, relative adrenal glands weight and plasma corticosterone level in the stressed mice. "

Related Drugs and Biologics

1.	HBK-14
2.	Nerve Growth Factor (NGF)
3.	Brain-Derived Neurotrophic Factor (BDNF)
4.	Scopolamine (Hyoscine)
5.	Corticosterone