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3-deoxy-dioctanoylphosphatidylinositol

has antineoplastic activity

Also Known As:

d-3-deoxy-diC8PI; d-3-deoxy-dioctanoylphosphatidylinositol

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Membrane Lipids: 1591
  - Phospholipids: 11903
    - Glycerophosphates: 118
      - Phosphatidic Acids: 358
        Glycerophospholipids: 689
        Phosphatidylinositols: 5099
        3-deoxy-dioctanoylphosphatidylinositol: 1

Experts

1.	Chiles, Thomas C: 1 article (11/2016)
2.	Dufort, Fay J: 1 article (11/2016)
3.	Gradziel, Cheryl S: 1 article (11/2016)
4.	Jewel, Delilah: 1 article (11/2016)
5.	Jordan, Peter A: 1 article (11/2016)
6.	Miller, Scott J: 1 article (11/2016)
7.	Roberts, Mary F: 1 article (11/2016)

Related Diseases

1.	Retinoblastoma (Glioblastoma, Retinal) 11/01/2016 - "d-3-Deoxy-dioctanoylphosphatidylinositol induces cytotoxicity in human MCF-7 breast cancer cells via a mechanism that involves downregulation of the D-type cyclin-retinoblastoma pathway."
2.	Breast Neoplasms (Breast Cancer) 11/01/2016 - "In MCF-7 breast cancer cells, with little constitutively active Akt, d-3-deoxy-diC8PI (but not l-compounds) decreases viability concomitant with increased cleavage of PARP and caspase 9, indicative of apoptosis. " 11/01/2016 - "d-3-Deoxy-dioctanoylphosphatidylinositol induces cytotoxicity in human MCF-7 breast cancer cells via a mechanism that involves downregulation of the D-type cyclin-retinoblastoma pathway."

Related Drugs and Biologics

1.	Caspase 9
2.	Cyclins