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12beta- O- (L- chloracetyl)- dammar- 20(22)- ene- 3beta,25- diol

structure in first source

Also Known As:

12-chloracetyl-PPD

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - 12beta-O-(L-chloracetyl)-dammar-20(22)-ene-3beta,25-diol: 1

Experts

1.	Qu, Fan Zhi: 1 article (03/2017)
2.	Sun, Yuan Yuan: 1 article (03/2017)
3.	Wang, Xu De: 1 article (03/2017)
4.	Zhao, Chen: 1 article (03/2017)
5.	Zhao, Yu Qing: 1 article (03/2017)

Related Diseases

1.	Stomach Neoplasms (Stomach Cancer) 03/05/2017 - "We found that compound 12-Chloracetyl-PPD resulted in a concentration-dependent inhibition of viability in prostate, breast, and gastric cancer cells, without affecting the viability of normal cell (human gastric epithelial cell line-GES-1, hair follicle dermal papilla cell line-HHDPC and rat myocardial cell line-H9C2). "
2.	Neoplasms (Cancer) 03/05/2017 - "In MDA-MB-435 and C4-2B cancer cells, 12-Chloracetyl-PPD induced G2/M cell cycle arrest, down-regulated mouse double minute 2 (MDM2) expression, up-regulated p53 expression, triggered apoptosis, and stimulated reactive oxygen species production. " 03/05/2017 - "Our results suggested that compound 12-Chloracetyl-PPD showed obvious anti-cancer activity based on delaying cell cycle arrest and inducing cell apoptosis by reactive oxygen species production, which supported development of 12-Chloracetyl-PPD as a potential agent for cancer chemotherapy." 03/05/2017 - "12-Chloracetyl-PPD, a novel dammarane derivative, shows anti-cancer activity via delay the progression of cell cycle G2/M phase and reactive oxygen species-mediate cell apoptosis."

Related Drugs and Biologics

1.	Reactive Oxygen Species (Oxygen Radicals)
2.	Dammaranes

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)