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SI221 compound

pyrazolo(3,4-d)pyrimidine derivative; SRC family kinases inhibitor; structure in first source

Also Known As:

SI221

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - SI221 compound: 3
  - Pyrimidines: 510
    - SI221 compound: 3

Experts

1.	Botta, Maurizio: 3 articles (01/2017 - 05/2015)
2.	Casini, Nadia: 3 articles (01/2017 - 05/2015)
3.	Forte, Iris Maria: 3 articles (01/2017 - 05/2015)
4.	Giordano, Antonio: 3 articles (01/2017 - 05/2015)
5.	Indovina, Paola: 3 articles (01/2017 - 05/2015)
6.	Pentimalli, Francesca: 3 articles (01/2017 - 05/2015)
7.	Schenone, Silvia: 3 articles (01/2017 - 05/2015)
8.	Ceccherini, Elisa: 2 articles (05/2015 - 05/2015)
9.	Boffo, Silvia: 1 article (01/2017)
10.	Cesari, Daniele: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 05/20/2015 - "SI221, which showed to be mainly effective against the SFK member YES, significantly reduced cell viability and induced apoptosis, without affecting non-tumor cells, such as primary human skin fibroblasts and differentiated C2C12 cells. " 05/20/2015 - "Moreover, SI221 decreased in vitro cell migration and invasion and reduced tumor growth in a RMS xenograft model. " 01/01/2017 - "Here, we challenged ES cell lines with a recently developed selective SFK inhibitor (a pyrazolo[3,4-d]pyrimidine derivative, called SI221), which was previously shown to be a valuable proapoptotic agent in other tumor types while not affecting normal cells. "
2.	Brain Neoplasms (Brain Tumor) 05/01/2015 - "Moreover, through in vitro pharmacokinetic assays, SI221 proved to have a high metabolic stability and a good potential to cross the blood brain barrier, which is an essential requirement for a drug intended to treat brain tumors. "

Related Drugs and Biologics

1.	pyrimidine