CL-55 compound

inhibits the type III secretion system; structure in first source

Also Known As:

N-(2,4-difluorophenyl)-4-(3-ethoxy-4-hydroxybenzyl)-5-oxo-5,6-dihydro-4H-(1,3,4)-thiadiazine-2-carboxamide; fluorothiazinon

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

1.	Sheremet, Anna B: 2 articles (01/2022 - 01/2021)
2.	Soloveva, Anna V: 2 articles (01/2022 - 01/2021)
3.	Zayakin, Egor S: 2 articles (01/2022 - 01/2021)
4.	Zigangirova, Nailya A: 2 articles (01/2022 - 01/2021)
5.	Bondareva, Nataliya E: 1 article (01/2022)
6.	Kapotina, Lidiya N: 1 article (01/2022)
7.	Koroleva, Ekaterina A: 1 article (01/2022)
8.	Luyksaar, Sergei I: 1 article (01/2022)
9.	Morgunova, Elena Y: 1 article (01/2022)
10.	Balunets, Denis V: 1 article (01/2021)

1.	Infections 11/30/2023 - "Fluorothiazinon (FT) is an anti-virulence drug developed to suppress the virulence of bacteria as opposed to bacterial death increasing host's immune response to infection and improving treatment to inhibit drug resistant bacteria. " 01/01/2021 - "Fluorothiazinon, a small-molecular inhibitor of T3SS, suppresses salmonella oral infection in mice."
2.	Sepsis (Septicemia) 01/01/2022 - "Preventative treatment with Fluorothiazinon suppressed Acinetobacter baumannii-associated septicemia in mice."
3.	Urinary Tract Infections (Urinary Tract Infection) 01/01/2023 - "Fluorothiazinon inhibits the virulence factors of uropathogenic Escherichia coli involved in the development of urinary tract infection."
4.	Pneumonia (Pneumonitis) 11/30/2023 - "Pharmacokinetics, quorum-sensing signal molecules and tryptophan-related metabolomics of the novel anti-virulence drug Fluorothiazinon in a Pseudomonas aeruginosa-induced pneumonia murine model."

1.	Virulence Factors (Pathogenicity Factors)
2.	Tryptophan (L-Tryptophan)