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PF-6409577

an AMPK activator; structure in first source

Also Known As:

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylic acid; PF-06409577

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - PF-6409577: 5

Experts

1.	Fang, Qian: 1 article (10/2022)
2.	Fu, Kequan: 1 article (10/2022)
3.	Guo, Dong: 1 article (10/2022)
4.	Liu, Hongli: 1 article (10/2022)
5.	Ren, Ying: 1 article (10/2022)
6.	Su, Limin: 1 article (10/2022)
7.	Wang, Junqi: 1 article (10/2022)
8.	Wang, Ruoqi: 1 article (10/2022)
9.	Yin, Long: 1 article (10/2022)
10.	Yuan, Haoxing: 1 article (10/2022)

Related Diseases

1.	Atherosclerosis 11/17/2023 - "In the current study, we found that the orally bioavailable and highly selective activator of AMPKβ1 complexes, PF-06409577, reduced atherosclerosis in two mouse models in a myeloid-derived AMPKβ1 dependent manner, suggesting a critical role for macrophages. " 11/17/2023 - "Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice."
2.	Non-alcoholic Fatty Liver Disease 05/01/2018 - "Together these data suggest that activation of AMPK β1 complexes with PF-06409577 is capable of impacting multiple facets of liver disease and represents a promising strategy for the treatment of NAFLD and NASH in humans." 05/01/2018 - "Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models."
3.	Flavivirus Infections 01/01/2018 - "Direct Activation of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by PF-06409577 Inhibits Flavivirus Infection through Modification of Host Cell Lipid Metabolism."
4.	Autosomal Dominant Polycystic Kidney (ADPKD) 10/01/2022 - "Overall, our data suggest that PF-06409577 holds therapeutic potential for ADPKD treatment." 10/01/2022 - "Herein, we adopted a drug repurposing strategy to explore the potential of PF-06409577, an AMPK activator for diabetic nephropathy, in cellular, ex vivo and in vivo models of ADPKD. "
5.	Osteosarcoma (Osteogenic Sarcoma) 01/01/2021 - "PF-06409577 Activates AMPK Signaling and Inhibits Osteosarcoma Cell Growth."

Related Drugs and Biologics

1.	Cholesterol
2.	TOR Serine-Threonine Kinases
3.	AMP-Activated Protein Kinases
4.	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)
5.	Messenger RNA (mRNA)
6.	Protein Kinases (Protein Kinase)
7.	Lipids
8.	Adenosine Monophosphate (AMP)