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AB-FUBINACA

a synthetic cannabinoid; structure in first source

Also Known As:

N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide

Networked: 11 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - Indazoles: 179
        AB-FUBINACA: 11
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indazoles: 179
      - AB-FUBINACA: 11

Experts

1.	Banister, Samuel D: 2 articles (01/2017 - 09/2015)
2.	Kassiou, Michael: 2 articles (01/2017 - 09/2015)
3.	Kevin, Richard C: 2 articles (01/2017 - 09/2015)
4.	McGregor, Iain S: 2 articles (01/2017 - 09/2015)
5.	Moir, Michael: 2 articles (01/2017 - 09/2015)
6.	Stuart, Jordyn: 2 articles (01/2017 - 09/2015)
7.	Wood, Katie E: 2 articles (01/2017 - 09/2015)
8.	Jeon, Ji-Hyeon: 1 article (10/2020)
9.	Kim, Dong Kyun: 1 article (10/2020)
10.	Kim, Sunjoo: 1 article (10/2020)

Related Diseases

1.	Seizures (Absence Seizure) 09/01/2016 - "AB-FUBINACA was one of the top three synthetic cannabinoids most frequently found in seizures and toxicological drug screening in Sweden (2013-2014). " 08/08/2022 - "No NPSs were seized until June 2021, when NPSs were found in two different seizures: Case #1 showed a bar of Cannabis resin containing a low level of Δ9THC = 0.57% associated to SC AB-FUBINACA in 4.5%; Case #2 showed a vegetal resinous substance (Δ9THC = 0.27%) with SC 5F-APINACA (4.1%) associated with methadone (1.0%). " 01/01/2017 - "In vivo studies showed that 5F-ADBINACA, AB-FUBINACA, and STS-135 induced hypothermia; increased pain threshold to both noxious mechanical and thermal stimuli; caused catalepsy; reduced motor activity; impaired sensorimotor responses (visual, acoustic, and tactile); caused seizures, myoclonia, and hyperreflexia; and promoted aggressiveness in mice. " 04/01/2019 - "New analytes were added based on reports from NMS Laboratories and the US Drug Enforcement Administration testing and drug seizures, which included etizolam, its major metabolite α-hydroxyetizolam as well as newer synthetic cannabinoids (5-fluoro ADB metabolite 7, AB-FUBINACA metabolite 3, AB-FUBINACA metabolite 4 and MDMB-FUBINACA metabolite M1) and synthetic cathinones (N-ethyl pentylone). "
2.	Catalepsy 01/01/2020 - "Adult male and female C57BL/6J mice were treated with AB-FUBINACA (0-3 mg/kg, i.p.) and tested repeatedly in the tetrad battery measuring catalepsy, antinociception, hypothermia, and locomotor activity. " 01/01/2017 - "In vivo studies showed that 5F-ADBINACA, AB-FUBINACA, and STS-135 induced hypothermia; increased pain threshold to both noxious mechanical and thermal stimuli; caused catalepsy; reduced motor activity; impaired sensorimotor responses (visual, acoustic, and tactile); caused seizures, myoclonia, and hyperreflexia; and promoted aggressiveness in mice. "
3.	Abnormal Reflex (Hyperreflexia) 01/01/2017 - "In vivo studies showed that 5F-ADBINACA, AB-FUBINACA, and STS-135 induced hypothermia; increased pain threshold to both noxious mechanical and thermal stimuli; caused catalepsy; reduced motor activity; impaired sensorimotor responses (visual, acoustic, and tactile); caused seizures, myoclonia, and hyperreflexia; and promoted aggressiveness in mice. "
4.	Breast Neoplasms (Breast Cancer) 10/08/2020 - "In this study, the inhibitory effects of AB-FUBINACA on eight major human cytochrome P450s (CYPs) and six uridine 5'-diphospho-glucuronosyltransferases (UGTs) of human liver microsomes, and on eight clinically important transport activities including organic cation transporters (OCT)1 and OCT2, organic anion transporters (OAT)1 and OAT3, organic anion transporting polypeptide transporters (OATP)1B1 and OATP1B3, P-glycoprotein, and breast cancer resistance protein (BCRP) in transporter-overexpressing cells were investigated. "
5.	Hypothermia 01/01/2020 - "Adult male and female C57BL/6J mice were treated with AB-FUBINACA (0-3 mg/kg, i.p.) and tested repeatedly in the tetrad battery measuring catalepsy, antinociception, hypothermia, and locomotor activity. " 09/16/2015 - "AB-FUBINACA and AB-PINACA dose-dependently induced hypothermia and bradycardia at doses of 0.3-3 mg/kg, and hypothermia was reversed by pretreatment with a CB1 (but not CB2) antagonist, indicating that these SCs are cannabimimetic in vivo, consistent with anecdotal reports of psychoactivity in humans. "

Related Drugs and Biologics

1.	Organic Anion Transporters
2.	Member 1 Subfamily B ATP Binding Cassette Transporter
3.	Uridine
4.	Proteins (Proteins, Gene)
5.	Peptides (Polypeptides)
6.	Cytochromes
7.	Cations
8.	Anions
9.	N- (adamantan- 1- yl)- 1- (5- fluoropentyl)- 1H- indole- 3- carboxamide
10.	Cannabinoids

Related Therapies and Procedures

1.	Induced Hypothermia