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zuotai

a metal ash preparation containing mostly beta-mercuric sulfide; used in Tibetan traditional medicine

Networked: 12 relevant articles (2 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Mercury Compounds: 73
  - zuotai: 12

Experts

1.	Li, Cen: 7 articles (01/2021 - 07/2014)
2.	Wei, Li-Xin: 7 articles (01/2021 - 07/2014)
3.	Liu, Jie: 5 articles (01/2021 - 07/2016)
4.	Li, Wen-Kai: 3 articles (01/2017 - 07/2016)
5.	Shang, Jing: 2 articles (04/2019 - 03/2019)
6.	Du, Yuzhi: 2 articles (03/2019 - 01/2018)
7.	Wei, Lixin: 2 articles (03/2019 - 01/2018)
8.	Du, Yu-Zhi: 2 articles (11/2016 - 07/2014)
9.	Li, Ying-Ying: 2 articles (11/2016 - 07/2016)
10.	Zhou, Zheng-Ping: 2 articles (11/2016 - 07/2016)

Related Diseases

1.	Body Weight (Weight, Body) 01/01/2017 - "Animal body weight gain was decreased by HgCl2 and to a lesser extent by MeHg, but unaltered after Zuotai and HgS. " 11/16/2016 - "Animal body weights were decreased by HgCl2 and to a lesser extent by MeHg, but unaltered after Zuotai and HgS. " 01/01/2018 - "Zuotai or imipramine significantly increased the body weight and the sucrose preference ratio in sucrose preference test, and dramatically improved motor activity in forced swimming test, tail suspension test, and open field test in CUMS mice. "
2.	Hypoxia (Hypoxemia) 03/18/2019 - "Taken together, in organisms with hypoxia induced oxidative stress 5-HT levels were found to be abnormally elevated, indicating that 5-HT could regulate oxidative stress, and the decrease in the 5-HT levels, behavioral abnormalities after treatment with cinnabar and Zuotai, we may conclude that the therapeutic and pharmacologic effect of cinnabar and Zuotai may be based on the regulation of 5-HT metabolism and relief of oxidative stress. " 03/18/2019 - "Further, our in vivo experiments revealed that the administration of cinnabar or prescription drug Zuotai in zebrafish reduced the reactive oxygen species (ROS) induced by hypoxia and cured behavioral abnormalities. "
3.	Inflammation (Inflammations) 07/01/2016 - "HgCl2 and MeHg produced spotted hepatocyte swelling and inflammation, while such lesions are mild in Zuotai and HgS-treated mice. " 07/01/2016 - "Mice were orally administrated with Zuotai (30 mg/kg), α-HgS (HgS, 30 mg/kg), HgCl2 (33.6 mg/kg), or CH3HgCl (3.1 mg/kg) for 7 days, and liver injury and gene expressions related to toxicity, inflammation and Nrf2 were examined. " 11/16/2016 - "HgCl2 and MeHg produced renal tubular vacuolation, interstitial inflammation and cell degeneration with protein cysts in the tubular lumen, while these pathological lesions were mild in Zuotai and HgS-treated mice. " 07/01/2016 - "HgCl2 and MeHg increased the expression of liver injury biomarker genes metallothionein-1 (MT-1) and heme oxygenase-1 (HO-1); the inflammation biomarkers early growth response gene (Egr1), glutathione S-transferase (Gst-mu), chemokine (mKC) and microphage inflammatory protein (MIP-2), while these changes were insignificant in Zuotai and HgS groups. "
4.	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/01/2021 - "Background: Zuotai (mainly β-HgS)-containing 70 Wei-Zhen-Zhu-Wan (70W, Rannasangpei) is a famous Tibetan medicine for treating cardiovascular and gastrointestinal diseases. We have shown that 70W protected against CCl 4 hepatotoxicity. CCl 4 is metabolized via cytochrome P450 (CYP) to produce reactive metabolites. " 01/01/2021 - "Background: Zuotai (mainly β-HgS)-containing 70 Wei-Zhen-Zhu-Wan (70W, Rannasangpei) is a famous Tibetan medicine for treating cardiovascular and gastrointestinal diseases. We have shown that 70W protected against CCl 4 hepatotoxicity. CCl 4 is metabolized via cytochrome P450 (CYP) to produce reactive metabolites. "
5.	Weight Gain 07/01/2014 - "Besides, no significant difference in weight gain was found between the Zuotai group and the control group. "

Related Drugs and Biologics

1.	Prescription Drugs
2.	Reactive Oxygen Species (Oxygen Radicals)
3.	Sucrose (Saccharose)
4.	Imipramine (Janimine)
5.	cinnabar (mercuric sulfide)
6.	Mercuric Chloride (Sublimate)
7.	Proteins (Proteins, Gene)
8.	Cytochrome P-450 Enzyme System (Cytochrome P450)
9.	Heme Oxygenase-1
10.	Chemokines

Related Therapies and Procedures

1.	Tibetan Traditional Medicine (Traditional Tibetan Medicine)
2.	Aftercare (After-Treatment)