Boron-10

08/01/2023 - "BNCT is considered to be a promising method for the treatment of malignant tumors, which ensures the selective destruction of malignant tumor cells by accumulating non-radioactive atomic boron-10 nuclei in them and subsequent irradiation with neutrons. "
01/01/2021 - "BNCT utilizes boronated agents to preferentially deliver boron-10 to tumors, which, after undergoing irradiation with neutrons, yields litihium-7 and an alpha particle. "
04/09/2020 - "Nonradioactive boron-10 atoms accumulated in tumor cells combining with the neutron beams produce two highly energetic particles that could eradicate the cell that takes it and the neighboring cells. "
12/01/2018 - "Boron-10 (10B) containing compounds that can accumulate in tumor tissue are expected to be suitable agents for BNCT. "
07/15/2016 - "Therefore, BNCT enables the application of a high dose of particle radiation selectively to tumor cells in which boron-10 compound has been accumulated. "

04/01/1972 - "Neuropathologic study of fourteen cases of malignant brain tumor treated by boron-10 slow neutron capture radiation."
01/23/2017 - "The tumor/brain boron-10 concentration ratio was higher with ACBC-BSH/CED than that of BPA/i.v. group. "
09/01/2002 - "Boron-10 is known to accumulate selectively only in brain tumor cells. "
11/15/2001 - "Ion microscopy revealed a consistent pattern of boron-10 microdistribution for both rat brain tumor models. "
05/01/1986 - "Boron-10 accumulated in the brain tumors. "

02/01/2000 - "The key to effective BNCT of tumours, such as glioblastoma multiforme (GBM), is the preferential accumulation of boron-10 in the tumour, including the infiltrating GBM cells, as compared with that in the vital structures of the normal brain. "
11/01/1994 - "In three cases, boron-10 was identified in glioblastoma cells by laser microprobe mass analysis. "
11/01/1994 - "Subcellular boron-10 localization in glioblastoma for boron neutron capture therapy with Na2B12H11SH."
03/21/2006 - "In the proposed concept, when the tumour region is loaded with boron-10 it is irradiated with neutrons (treatment used for head and neck cancers, melanoma and glioblastoma for over 40 years in Japan and Europe). "
02/01/1998 - "Boron-10 (10B) concentrations were measured in 107 surgical samples from 15 patients with glioblastoma multiforme who were infused with 95 atom% 10B-enriched p-boronophenylalanine (BPA) intravenously for 2 h just prior to surgery at doses ranging from 98 to 290 mg BPA/kg body weight. "

02/01/2013 - "In this study, FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas. "
02/01/2013 - "Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas."

01/01/2019 - "Electroporation optimizes the uptake of boron-10 by tumor for boron neutron capture therapy (BNCT) mediated by GB-10: a boron biodistribution study in the hamster cheek pouch oral cancer model."