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Thorium-227

Also Known As:

227Th radioisotope; Th-227 radioisotope

Networked: 18 relevant articles (5 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hagemann, Urs B: 6 articles (01/2021 - 10/2016)
2.	Karlsson, Jenny: 6 articles (01/2021 - 10/2016)
3.	Mumberg, Dominik: 5 articles (01/2021 - 01/2019)
4.	Bjerke, Roger M: 5 articles (01/2020 - 10/2016)
5.	Ellingsen, Christine: 4 articles (01/2021 - 01/2019)
6.	Cuthbertson, Alan S: 4 articles (01/2020 - 10/2016)
7.	Ryan, Olav B: 4 articles (01/2020 - 10/2016)
8.	Hammer, Stefanie: 3 articles (01/2021 - 01/2020)
9.	Hennekes, Hartwig: 3 articles (01/2021 - 01/2019)
10.	Schatz, Christoph A: 3 articles (01/2021 - 01/2019)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 01/01/2020 - "Preclinical Efficacy of a PSMA-Targeted Thorium-227 Conjugate (PSMA-TTC), a Targeted Alpha Therapy for Prostate Cancer." 01/01/2021 - "Darolutamide Potentiates the Antitumor Efficacy of a PSMA-targeted Thorium-227 Conjugate by a Dual Mode of Action in Prostate Cancer Models."
2.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/01/2016 - "In Vitro and In Vivo Efficacy of a Novel CD33-Targeted Thorium-227 Conjugate for the Treatment of Acute Myeloid Leukemia." 10/01/2016 - "We describe the preparation and use of a CD33-targeted thorium-227 conjugate (CD33-TTC), which binds to the sialic acid receptor CD33 for the treatment of acute myeloid leukemia (AML). "
3.	Neoplasm Metastasis (Metastasis) 06/29/2023 - "Efficacy of a HER2-Targeted Thorium-227 Conjugate in a HER2-Positive Breast Cancer Bone Metastasis Model."
4.	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/01/2023 - "Here, based on the previous encouraging findings with monotherapy, we investigated the efficacy of the mesothelin-targeted thorium-227 conjugate (MSLN-TTC) both as monotherapy and in combination with chemotherapies and antiangiogenic compounds in ovarian and cervical cancer models expressing p-gp. "
5.	Breast Neoplasms (Breast Cancer) 06/29/2023 - "Efficacy of a HER2-Targeted Thorium-227 Conjugate in a HER2-Positive Breast Cancer Bone Metastasis Model."

Related Drugs and Biologics

1.	Mesothelin
2.	darolutamide
3.	Radiopharmaceuticals
4.	Radioisotopes (Radionuclides)
5.	Chelating Agents
6.	Monoclonal Antibodies
7.	Actinium-225
8.	Radium-223
9.	Antigens
10.	Trastuzumab (Herceptin)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Radioimmunotherapy