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aphanin

antineoplastic from Amoora rohituka; structure in first source

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - aphanin: 1

Experts

1.	Catapano, Carlo V: 1 article (09/2016)
2.	Rabi, Thangaiyan: 1 article (09/2016)

Related Diseases

1.

Pancreatic Neoplasms (Pancreatic Cancer)

09/01/2016 - "The results of our study have important implications for the development of aphanin as potential novel agent for the treatment of K-Ras mutant pancreatic cancer, and STAT3-cMyc-cyclinD1 axis may serve as an important predictive biomarker for the therapeutic efficacy."
09/01/2016 - "We found aphanin exhibited antiproliferative effects, caused G0-G1 cell cycle arrest, inhibits K-Ras G12D mutant activity by decreased STAT3, p-STAT3, Akt, p-Akt, cyclin D1 and c-Myc expressions, and induced apoptosis in pancreatic cancer HPAF-II (ΔKRAS G12D ) cells. "
09/01/2016 - "Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells."

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Cyclin D1
3.	Triterpenes