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dolcanatide

A guanylyl cyclase C agonist used in the treatment of colitis.

Also Known As:

SP-333; asn-asp-glu-cys-glu-leu-cys-val-asn-val-ala-cys-thr-gly-cys-leu (4->12),(7->15)-bis(disulfide)

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - dolcanatide: 5

Experts

1.	Waldman, Scott A: 2 articles (12/2021 - 01/2018)
2.	Foss, John A: 2 articles (05/2018 - 11/2015)
3.	Shailubhai, Kunwar: 2 articles (05/2018 - 11/2015)
4.	Della'Zanna, Gary: 1 article (12/2021)
5.	Foster, Nathan R: 1 article (12/2021)
6.	Henry, Christopher H: 1 article (12/2021)
7.	Kastenberg, David M: 1 article (12/2021)
8.	Katz, Leo C: 1 article (12/2021)
9.	Kraft, Walter K: 1 article (12/2021)
10.	Limburg, Paul J: 1 article (12/2021)

Related Diseases

1.	Carcinogenesis 12/02/2021 - "These data reveal that the enhanced stability of dolcanatide, with persistence along the rostral-caudal axis of the small and large intestine, is inadequate to regulate GUCY2C across the colorectum to prevent tumorigenesis. "
2.	Inflammation (Inflammations) 11/06/2015 - "Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis."
3.	Hypersensitivity (Allergy) 05/07/2018 - "Consistent with these findings, plecanatide and dolcanatide showed potent anti-nociceptive activity in rat visceral hypersensitivity models. " 05/07/2018 - "To investigate the effects of plecanatide and dolcanatide on maintenance of paracellular permeability, integrity of tight junctions and on suppression of visceral hypersensitivity. " 05/07/2018 - "Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models."
4.	Diarrhea 01/01/2018 - "Its ligands include bacterial heat-stable enterotoxins responsible for traveler's diarrhea, the endogenous peptide hormones uroguanylin and guanylin, and the synthetic agents, linaclotide, plecanatide, and dolcanatide. "
5.	Constipation 08/01/2015 - "Plecanatide is currently tested as a potential therapeutic in diseases related to constipation and SP-333 is a promising drug in ulcerative colitis treatment. "

Related Drugs and Biologics

1.	plecanatide
2.	uroguanylin
3.	Peptide Hormones (Polypeptide Hormones)
4.	Ligands
5.	Guanylate Cyclase (Guanylyl Cyclase)
6.	Guanosine Monophosphate (5' Guanylic Acid)
7.	Enterotoxins (Enterotoxin)
8.	Guanylyl Cyclase C Agonists
9.	linaclotide
10.	guanylin