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1- ((2- methylbenzimidazol- 1- yl)methyl)- 2- oxoindolin- 3- ylidene)amino)thiourea

has antiviral activity; structure in first source

Also Known As:

MBZM-N-IBT

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - 1-((2-methylbenzimidazol-1-yl)methyl)-2-oxoindolin-3-ylidene)amino)thiourea: 3
    - Indoles: 200
      - Isatin: 189
        1-((2-methylbenzimidazol-1-yl)methyl)-2-oxoindolin-3-ylidene)amino)thiourea: 3

Experts

1.	Chattopadhyay, Soma: 3 articles (01/2022 - 02/2016)
2.	Mamidi, Prabhudutta: 3 articles (01/2022 - 02/2016)
3.	Subudhi, Bharat Bhusan: 3 articles (01/2022 - 02/2016)
4.	Chattopadhyay, Subhasis: 2 articles (01/2022 - 02/2016)
5.	Datey, Ankita: 2 articles (01/2022 - 01/2021)
6.	De, Saikat: 2 articles (01/2022 - 01/2021)
7.	Kumar, Abhishek: 2 articles (01/2021 - 02/2016)
8.	Mishra, Priyadarsee: 2 articles (01/2021 - 02/2016)
9.	Nayak, Tapas Kumar: 2 articles (01/2021 - 02/2016)
10.	Saswat, Tanuja: 2 articles (01/2021 - 02/2016)

Related Diseases

1.	Infections 01/01/2022 - "In conclusion, it can be suggested that this novel compound MBZM-N-IBT has been demonstrated to be a potential anti-CHIKV molecule in vitro, in vivo, and ex vivo and fulfilled all the criteria to investigate further for successful treatment of CHIKV infection." 01/01/2021 - "Similar effect of MBZM-N-IBT was also noticed in the Raw 264.7 and BHK 21 cells after HSV-1 infection. " 01/01/2021 - "The time of addition experiment revealed the capacity of MBZM-N-IBT to inhibit HSV-1 at early as well as late stages of infection in the Vero cells. " 01/01/2021 - "Inhibition of herpes simplex virus-1 infection by MBZM-N-IBT: in silico and in vitro studies." 01/01/2022 - "Furthermore, MBZM-N-IBT restricted CHIKV infection and inflammation in vivo, leading to reduced clinical scores and complete survival of C57BL/6 mice. "
2.	Herpes Simplex 01/01/2021 - "Inhibition of herpes simplex virus-1 infection by MBZM-N-IBT: in silico and in vitro studies."
3.	Chikungunya Fever 01/01/2022 - "MBZM-N-IBT, a Novel Small Molecule, Restricts Chikungunya Virus Infection by Targeting nsP2 Protease Activity In Vitro, In Vivo, and Ex Vivo."
4.	Inflammation (Inflammations) 01/01/2022 - "Furthermore, MBZM-N-IBT restricted CHIKV infection and inflammation in vivo, leading to reduced clinical scores and complete survival of C57BL/6 mice. "

Related Drugs and Biologics

1.	Viral RNA
2.	Peptide Hydrolases (Proteases)