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HAO472

has antineoplastic activity; structure in first source

Also Known As:

L-alanine-(14-oridonin) ester trifluoroacetate

Networked: 3 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Alanine: 4133
    - HAO472: 3
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Kaurane Diterpenes: 93
        HAO472: 3

Experts

1.	Gao, Xiang: 1 article (01/2020)
2.	Hu, Xu: 1 article (01/2020)
3.	Hua, Huiming: 1 article (01/2020)
4.	Li, Dahong: 1 article (01/2020)
5.	Li, Zhanlin: 1 article (01/2020)
6.	Wang, Yan: 1 article (01/2020)
7.	Xiao, Yan: 1 article (01/2020)
8.	Xu, Jinyi: 1 article (01/2020)
9.	Xu, Shengtao: 1 article (01/2020)
10.	Zang, Linghe: 1 article (01/2020)

Related Diseases

1.	Neoplasms (Cancer) 10/21/2016 - "HAO472) have been designed and synthesized, and have contributed to substantial progress in the identification of new agents and relevant molecular mechanistic studies toward the treatment of human cancers and other diseases. " 01/01/2020 - "HAO472 hewed out new avenues to explore the therapeutic properties of oridonin derivatives and develop promising treatment of cancer originated from naturally derived drug candidates. "
2.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 02/01/2016 - "To confirm the potential therapeutic efficacy of HAO472 against inflammatory bowel disease (IBD), we investigated the modulatory functions of HAO472 in a mouse model of trinitrobenzene sulfonic acid (TNBS)-induced colitis. "
3.	Inflammation (Inflammations) 02/01/2016 - "HAO472 significantly ameliorated the clinical symptoms, reduced the severity of the inflammation and decreased mortality in the mouse model. " 02/01/2016 - "HAO472 has positive effects on TNBS-induced colitis by modulating the subsets and functions of lymphocytes, suppressing inflammation and inhibiting the nuclear translocation of NF-κB p65 subunits."
4.	Colitis 02/01/2016 - "HAO472 has positive effects on TNBS-induced colitis by modulating the subsets and functions of lymphocytes, suppressing inflammation and inhibiting the nuclear translocation of NF-κB p65 subunits." 02/01/2016 - "To confirm the potential therapeutic efficacy of HAO472 against inflammatory bowel disease (IBD), we investigated the modulatory functions of HAO472 in a mouse model of trinitrobenzene sulfonic acid (TNBS)-induced colitis. "

Related Drugs and Biologics

1.	Sulfonic Acids
2.	oridonin