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Y-QA31

a dopamine D3 receptor antagonist with antipsychotic activity; structure in first source

Also Known As:

N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-2-benzothiazolinone-6-carboxamide

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - Benzothiazoles: 40
        Y-QA31: 1
  - Piperazines: 26
    - Y-QA31: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzothiazoles: 40
      - Y-QA31: 1

Experts

1.	Cong, Bin: 1 article (03/2016)
2.	Gou, Hong-yan: 1 article (03/2016)
3.	Li, Fei: 1 article (03/2016)
4.	Li, Jin: 1 article (03/2016)
5.	Lu, Guan-yi: 1 article (03/2016)
6.	Song, Rui: 1 article (03/2016)
7.	Su, Rui-bin: 1 article (03/2016)
8.	Sun, Xue: 1 article (03/2016)
9.	Wu, Ning: 1 article (03/2016)
10.	Yang, Ri-fang: 1 article (03/2016)

Related Diseases

1.	Cognitive Dysfunction 03/01/2016 - "Moreover, Y-QA31 itself did not affect spontaneous locomotion or induce cataleptic response until its dose reached 120 mg/kg. Y-QA31 is a selective D3R antagonist that exhibits antipsychotic effects in some animal models with positive symptoms and cognitive disorder and less extrapyramidal side effects."
2.	Schizophrenia (Dementia Praecox) 03/01/2016 - "Y-QA31, a novel dopamine D3 receptor antagonist, exhibits antipsychotic-like properties in preclinical animal models of schizophrenia." 03/01/2016 - "The antipsychotic profile of Y-QA31 was characterized in mouse models for the positive symptoms and cognitive deficits of schizophrenia and extrapyramidal side effects with haloperidol and clozapine as positive controls. "

Related Drugs and Biologics

1.	Dopamine D3 Receptors
2.	Antipsychotic Agents (Antipsychotics)
3.	Haloperidol (Haldol)
4.	Clozapine (Clozaril)