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LCX001

an ampakine, which modulates AMPA receptors; structure in first source

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxadiazoles: 146
        LCX001: 1

Experts

1.	Dai, Wei: 1 article (01/2019)
2.	Gao, Xiang: 1 article (01/2019)
3.	Li, Yu-Lei: 1 article (01/2019)
4.	Su, Rui-Bin: 1 article (01/2019)
5.	Xiao, Dian: 1 article (01/2019)
6.	Yong, Zheng: 1 article (01/2019)
7.	Zhou, Xin-Bo: 1 article (01/2019)

Related Diseases

1.

Respiratory Insufficiency (Respiratory Failure)

01/01/2019 - "The Impact and Mechanism of a Novel Allosteric AMPA Receptor Modulator LCX001 on Protection Against Respiratory Depression in Rodents."
01/01/2019 - "To resolve this issue, novel positive AMPA modulators, LCX001, was tested to alleviate respiratory depression triggered by different drugs. "
01/01/2019 - "Results showed that LCX001 effectively rescued and prevented opioid (fentanyl and TH-030418), propofol, and pentobarbital-induced respiratory depression by strengthening respiratory frequency and minute ventilation. "

Related Drugs and Biologics

1.	AMPA Receptors (AMPA Receptor)
2.	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)
3.	Propofol (Diprivan)
4.	Pentobarbital (Nembutal)
5.	Fentanyl (Sublimaze)
6.	Opioid Analgesics (Opioids)
7.	7- (1- hydroxy- 1- methyl- 3- (thien- 3- yl)propyl)- 6,14- ethanotetrahydrooripavine