RX-111

an NSAID that inhibits protein binding to glycosaminoglycans; structure in first source

Also Known As:

2-((4-((diethylamino)sulfonyl)benzoyl)amino)-3-(benzothiazol-2-yl)-6-ethyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridine

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - RX-111: 1
  - Pyridines: 88
    - RX-111: 1
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - RX-111: 1

Experts

1.	Gregor, Paul: 1 article (04/2016)
2.	Harris, Nicholas: 1 article (04/2016)
3.	Il'kova, Gabriela: 1 article (04/2016)
4.	Juhas, Stefan: 1 article (04/2016)
5.	Karin, Nathan: 1 article (04/2016)
6.	Kogan, Faina Yurgenzon: 1 article (04/2016)
7.	Koppel, Juraj: 1 article (04/2016)
8.	Lahmy, Orly: 1 article (04/2016)
9.	Wildbaum, Gizi: 1 article (04/2016)
10.	Zhuk, Regina: 1 article (04/2016)

Related Diseases

1.	Hypersensitivity (Allergy) 04/01/2016 - "Delayed-type hypersensitivity (DTH) and tri-nitrobenzene sulfonic acid (TNBS)-induced colitis in mice and experimental autoimmune encephalomyelitis (EAE) in rats were used to assay anti-inflammatory activity of RX-111 in vivo. " 04/01/2016 - "Mechanism of action and efficacy of RX-111, a thieno[2,3-c]pyridine derivative and small molecule inhibitor of protein interaction with glycosaminoglycans (SMIGs), in delayed-type hypersensitivity, TNBS-induced colitis and experimental autoimmune encephalomyelitis."
2.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 04/01/2016 - "Delayed-type hypersensitivity (DTH) and tri-nitrobenzene sulfonic acid (TNBS)-induced colitis in mice and experimental autoimmune encephalomyelitis (EAE) in rats were used to assay anti-inflammatory activity of RX-111 in vivo. " 04/01/2016 - "Mechanism of action and efficacy of RX-111, a thieno[2,3-c]pyridine derivative and small molecule inhibitor of protein interaction with glycosaminoglycans (SMIGs), in delayed-type hypersensitivity, TNBS-induced colitis and experimental autoimmune encephalomyelitis."
3.	Colitis 04/01/2016 - "RX-111 was efficacious in the mouse model of inflammatory bowel disease, TNBS-induced colitis and the rat model of multiple sclerosis, EAE. " 04/01/2016 - "Delayed-type hypersensitivity (DTH) and tri-nitrobenzene sulfonic acid (TNBS)-induced colitis in mice and experimental autoimmune encephalomyelitis (EAE) in rats were used to assay anti-inflammatory activity of RX-111 in vivo. " 04/01/2016 - "Mechanism of action and efficacy of RX-111, a thieno[2,3-c]pyridine derivative and small molecule inhibitor of protein interaction with glycosaminoglycans (SMIGs), in delayed-type hypersensitivity, TNBS-induced colitis and experimental autoimmune encephalomyelitis."
4.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 04/01/2016 - "RX-111 was efficacious in the mouse model of inflammatory bowel disease, TNBS-induced colitis and the rat model of multiple sclerosis, EAE. "
5.	Multiple Sclerosis 04/01/2016 - "RX-111 was efficacious in the mouse model of inflammatory bowel disease, TNBS-induced colitis and the rat model of multiple sclerosis, EAE. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Glycosaminoglycans
3.	pyridine
4.	Sulfonic Acids
5.	nitrobenzene

Related Therapies and Procedures

1.	Therapeutics