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AMRI-59

inhibits peroxiredoxin I; structure in first source

Also Known As:

N-(3-acetylphenyl)-4-(biphenyl-4-ylmethyl)piperidine-1-carboxamide

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Acetophenones: 16
    - AMRI-59: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - AMRI-59: 2

Experts

1.	Chang, Tong-Shin: 2 articles (12/2017 - 03/2016)
2.	Park, Jong Kuk: 2 articles (12/2017 - 03/2016)
3.	Um, Hong-Duck: 2 articles (12/2017 - 03/2016)
4.	Cho, Jeong Hyun: 1 article (12/2017)
5.	Hong, Wan Gi: 1 article (12/2017)
6.	Hwang, Sang-Gu: 1 article (12/2017)
7.	Kim, Ju Yeon: 1 article (12/2017)
8.	Lee, EunAh: 1 article (12/2017)
9.	Song, Jie-Young: 1 article (12/2017)
10.	Baek, Jin Young: 1 article (03/2016)

Related Diseases

1.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/26/2017 - "In this study, we examined whether AMRI-59 acts as a radiosensitizer in non-small cell lung cancer cells using clonogenic assays. "
2.	Neoplasms (Cancer) 12/26/2017 - "In a xenograft assay using NCI-H460 and NCI-H1299, combined treatment with AMRI-59 and IR delayed tumor growth by 26.98 and 14.88 days, compared with controls, yielding enhancement factors of 1.73 and 1.37, respectively. " 12/26/2017 - "AMRI-59 activity in vivo was examined by co-treating nude mice with the compound and γ-ionizing radiation (IR), followed by measurement of tumor volumes and apoptosis. " 03/10/2016 - "Moreover, significant antitumor activity of AMRI-59 was observed in mouse tumor xenograft model implanted with A549 cells with no apparent acute toxicity. " 03/10/2016 - "Effective Killing of Cancer Cells Through ROS-Mediated Mechanisms by AMRI-59 Targeting Peroxiredoxin I."
3.	Adenocarcinoma of Lung 03/10/2016 - "AMRI-59 increased cellular ROS, leading to the activation of both mitochondria- and apoptosis signal-regulated kinase-1-mediated signaling pathways, resulting in apoptosis of A549 human lung adenocarcinoma. "

Related Drugs and Biologics

1.	Peroxiredoxins