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ZCL278

antiviral

Also Known As:

4-(3-(2-(4-bromo-2-chloro-phenoxy)-acetyl)-thioureido)-N-(4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Yan-Hua: 2 articles (01/2019 - 01/2013)
2.	Lu, Qun: 2 articles (01/2019 - 01/2013)
3.	Zhao, Yaxue: 2 articles (01/2019 - 01/2013)
4.	Zhou, Huchen: 2 articles (01/2019 - 01/2013)
5.	Chen, Guangxin: 1 article (01/2022)
6.	Cui, Jia: 1 article (01/2022)
7.	Li, Ping: 1 article (01/2022)
8.	Wen, Da: 1 article (01/2022)
9.	Wu, Changxin: 1 article (01/2022)
10.	Xiong, Qiuhong: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "Herein, we report that ZCL367 is a bona fide Cdc42 inhibitor that suppressed cancer development and ZCL278 can act as a partial Cdc42 agonist. " 01/22/2013 - "Thus, ZCL278 is a small molecule that specifically targets Cdc42-ITSN interaction and inhibits Cdc42-mediated cellular processes, thus providing a powerful tool for research of Cdc42 subclass of Rho GTPases in human pathogenesis, such as those of cancer and neurological disorders."
2.	Vesicular Stomatitis 05/01/2016 - "While studying the potential role of the actin network and one of its master regulators, the small GTPase Cdc42, during Junin virus (JUNV) entry, we serendipitously uncovered the small molecule ZCL278, reported to inhibit Cdc42 function as an entry inhibitor for JUNV and for vesicular stomatitis virus, lymphocytic choriomeningitis virus, and dengue virus but not for the nonenveloped poliovirus. "
3.	Prostatic Neoplasms (Prostate Cancer) 01/22/2013 - "ZCL278 suppresses Cdc42-mediated neuronal branching and growth cone dynamics as well as actin-based motility and migration in a metastatic prostate cancer cell line (i.e., PC-3) without disrupting cell viability. "
4.	Nervous System Diseases (Neurological Disorders) 01/22/2013 - "Thus, ZCL278 is a small molecule that specifically targets Cdc42-ITSN interaction and inhibits Cdc42-mediated cellular processes, thus providing a powerful tool for research of Cdc42 subclass of Rho GTPases in human pathogenesis, such as those of cancer and neurological disorders."
5.	Neoplasm Metastasis (Metastasis) 07/22/2022 - "Importantly, treatment with ZCL278, a specific inhibitor of Cdc42, dramatically inhibited the attachment of ARHGEF37-overexpressing HCC cells to endothelial cells, and the adherence and extravasation in the lung alveoli, resulting in suppression of lung metastasis in mice. "

Related Drugs and Biologics

1.	rho GTP-Binding Proteins (rho GTP-Binding Protein)
2.	Monomeric GTP-Binding Proteins
3.	wiskostatin