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VNPT55

has antineoplastic activity; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Androstanes: 11
      - Androstenes: 5
        Androstadienes: 1
        VNPT55: 2
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - VNPT55: 2

Experts

1.	Kwegyir-Afful, Andrew K: 2 articles (11/2016 - 09/2015)
2.	Njar, Vincent C O: 2 articles (11/2016 - 09/2015)
3.	Purushottamachar, Puranik: 2 articles (11/2016 - 09/2015)
4.	Bruno, Robert D: 1 article (11/2016)
5.	Murigi, Francis N: 1 article (11/2016)
6.	Ramalingam, Senthilmurugan: 1 article (09/2015)
7.	Ramamurthy, Vidya P: 1 article (09/2015)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 11/01/2016 - "Our results suggest that gal/VNPT55 could become promising agents for the prevention and/or treatment of all stages of prostate cancer." 11/01/2016 - "Thus, we hypothesized that gal and its new analog, VNPT55, could modulate oncogenic mRNA translation and prostate cancer cell migration and invasion. " 11/01/2016 - "Galeterone and VNPT55 disrupt Mnk-eIF4E to inhibit prostate cancer cell migration and invasion." 09/29/2015 - "Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts in vivo." 11/01/2016 - "We report that gal and VNPT55 profoundly inhibit migration and invasion of prostate cancer cells, possibly by down-regulating protein expression of several EMT markers (Snail, Slug, N-cadherin, vimentin, and MMP-2/-9) via antagonizing the Mnk-eIF4E axis. "
2.	Neoplasms (Cancer) 09/29/2015 - "The effects of gal and VNPT55 were analyzed on f-AR and AR-Vs (AR-V7/ARv567es) in LNCaP, CWR22Rv1 and DU145 (transfected with AR-Vs) human PC cells in vitro and CRPC tumor xenografts. "

Related Drugs and Biologics

1.	3- hydroxy- 17- (1H- benzimidazole- 1- yl)androsta- 5,16- diene
2.	Cytochromes c (Cytochrome c)
3.	Matrix Metalloproteinases (MMPs)
4.	Cadherins (E-Cadherin)
5.	Vimentin
6.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Castration