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5- methyl- 3- (((1- (4- (nitrooxy)butanoyloxy)ethoxy)carbonylamino)methyl)hexanoic acid

a nitric oxide donor; structure in first source

Also Known As:

NCX1404

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Almirante, Nicoletta: 1 article (05/2016)
2.	Bastia, Elena: 1 article (05/2016)
3.	Brambilla, Stefania: 1 article (05/2016)
4.	Impagnatiello, Francesco: 1 article (05/2016)
5.	Ravani, Annalisa: 1 article (05/2016)
6.	Storoni, Laura: 1 article (05/2016)
7.	Targa, Martina: 1 article (05/2016)
8.	Varani, Katia: 1 article (05/2016)
9.	Vincenzi, Fabrizio: 1 article (05/2016)

Related Diseases

1.	Hyperalgesia 05/01/2016 - "However, NCX1404 resulted in disease-modifying properties when administered daily for 21 days, as indicated by the time- and dose-dependent reversal of STZ-induced mechanical allodynia (paw withdrawal threshold [PWT]Veh_21d= 1.3 ± 0.15 g for vehicle; PWTNCX1404_21d= 1.4 ± 0.5 g, 2.9 ± 0.2 g* and 4.1 ± 0.2 g, respectively for 19, 63, and 190μmol/kg, oral gavage [PO] of NCX1404; P< 0.05 versus vehicle). "
2.	Diabetic Neuropathies (Diabetic Neuropathy) 05/01/2016 - "Repeated Dosing with NCX1404, a Nitric Oxide-Donating Pregabalin, Re-establishes Normal Nociceptive Responses in Mice with Streptozotocin-Induced Painful Diabetic Neuropathy." 05/01/2016 - "NCX1404 [(3S)-5-methyl-3-(((1-(4-(nitrooxy)butanoyloxy)ethoxy)carbonylamino) methyl)hexanoic acid] is a novel nitric oxide (NO)-donating pregabalin that is readily absorbed and processed in vivo to pregabalin and NO. We determined the antiallodynic response of NCX1404 after acute or after 7, 14, and 21 days of repeated daily oral dosing in mice with streptozotocin (STZ)-induced painful diabetic neuropathy (PDN). "

Related Drugs and Biologics

1.	Streptozocin (Streptozotocin)
2.	Nitric Oxide (Nitrogen Monoxide)
3.	Pregabalin (Lyrica)
4.	hexanoic acid (hexanoate)