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CAY10444

a sphingosine-1-phosphate receptor 3 antagonist

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - Thiazolidines: 105
      - CAY10444: 5

Experts

1.	Chen, Hongping: 1 article (01/2022)
2.	Fan, Xuehui: 1 article (01/2022)
3.	Jiang, Fangchao: 1 article (01/2022)
4.	Li, Guozhong: 1 article (01/2022)
5.	Li, Meng: 1 article (01/2022)
6.	Song, Jihe: 1 article (01/2022)
7.	Tang, Zhanbin: 1 article (01/2022)
8.	Wang, Yingju: 1 article (01/2022)
9.	Wei, Wan: 1 article (01/2022)
10.	Xu, Chen: 1 article (01/2022)

Related Diseases

1.	Brain Ischemia (Cerebral Ischemia) 01/01/2022 - "The S1PR3-specific inhibitor CAY10444 was injected into the abdominal cavity of mice after cerebral ischemia/reperfusion (I/R) injury, and changes in the expression of blood-brain barrier-related molecules were measured using PCR, western blotting, and immunofluorescence staining. " 10/10/2018 - "To identify S1P3 as a pathogenic factor in cerebral ischemia, we employed a specific S1P3 antagonist, CAY10444. "
2.	Brain Edema (Cerebral Edema) 01/01/2022 - "After the administration of CAY10444, brain edema and neurological deficits in mice were ameliorated. " 01/01/2021 - "Moreover, reductions in brain edema volume, amelioration of BBB integrity, and improvements in behavioral deficits were achieved after the administration of CAY10444, an S1PR3 antagonist, to rats. "
3.	Brain Infarction 10/10/2018 - "Inhibiting S1P3 immediately after reperfusion with CAY10444 significantly reduced tMCAO-induced brain infarction, neurological deficit, and neurodegeneration. "
4.	Spinal Cord Injuries (Spinal Cord Injury) 01/01/2018 - "S1P/S1PR3 signaling mediated proliferation of pericytes via Ras/pERK pathway and CAY10444 had beneficial effects on spinal cord injury."
5.	Ischemia 01/01/2022 - "CAY10444 rescued the decreased expression of the tight junction (TJ) proteins zonula occludens 1 (ZO1) and occludin after ischemia induced by transient MCAO (tMCAO) and reduced the increase in aquaporin 4 (AQP4) levels after tMCAO, preserving the integrity of the BBB. "

Related Drugs and Biologics

1.	Occludin
2.	Aquaporin 4
3.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics