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YU238259

a DNA double-strand break repair inhibitor; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Abriola, Laura: 1 article (10/2015)
2.	Fernandez, Rafael J: 1 article (10/2015)
3.	Glazer, Peter M: 1 article (10/2015)
4.	Hoyer, Denton: 1 article (10/2015)
5.	Hungerford, William: 1 article (10/2015)
6.	Liu, Yanfeng: 1 article (10/2015)
7.	Merkel, Janie: 1 article (10/2015)
8.	Peterson-Roth, Elizabeth: 1 article (10/2015)
9.	Pike, Luke R G: 1 article (10/2015)
10.	Qian, Jack M: 1 article (10/2015)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 09/28/2023 - "DNA Double-Strand Break Repair Inhibitors: YU238259, A12B4C3 and DDRI-18 Overcome the Cisplatin Resistance in Human Ovarian Cancer Cells, but Not under Hypoxia Conditions."
2.	Neoplasms (Cancer) 10/01/2015 - "YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors." 10/01/2015 - "These findings suggest that YU238259 or related small molecules may have clinical benefit to patients with advanced BRCA2-negative tumors, either as a monotherapy or as an adjuvant to radiotherapy and certain chemotherapies. " 10/01/2015 - "Further, growth of BRCA2-deficient human tumor xenografts in nude mice is significantly delayed by YU238259 treatment even in the absence of concomitant DNA-damaging therapy. "
3.	Hypoxia (Hypoxemia) 09/28/2023 - "DNA Double-Strand Break Repair Inhibitors: YU238259, A12B4C3 and DDRI-18 Overcome the Cisplatin Resistance in Human Ovarian Cancer Cells, but Not under Hypoxia Conditions."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Cisplatin (Platino)
3.	3,3'- (1H,3'H- 5,5'- bibenzo(d)imidazole- 2,2'- diyl)dianiline
4.	2- (1- hydroxyundecyl)- 1- (4- nitrophenylamino)- 6- phenyl- 6,7a- dihydro- 1H- pyrrolo(3,4- b)pyridine- 5,7(2H,4aH)- dione

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Drug Therapy (Chemotherapy)