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oroxin A

has antineoplastic activity; isolated from Oroxylum indicum; structure in first source

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - Glucosides: 639
    - oroxin A: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        oroxin A: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        oroxin A: 3

Experts

1.	Chen, Chen: 1 article (01/2022)
2.	Cheng, Gao: 1 article (01/2022)
3.	Cheng, Xingdong: 1 article (01/2022)
4.	Hao, Shuang: 1 article (01/2022)
5.	Huang, Jian: 1 article (01/2022)
6.	Huang, Tingting: 1 article (01/2022)
7.	Shu, Liliang: 1 article (01/2022)
8.	Wang, Chunhui: 1 article (01/2022)
9.	Wang, Shixiong: 1 article (01/2022)
10.	Zhang, Qiaoyun: 1 article (01/2022)

Related Diseases

1.	Prediabetic State (Prediabetes) 01/01/2018 - "Oroxin A also improved the complications of prediabetes, such as lipid metabolism dysfunction and liver injury. " 01/01/2018 - "Oroxin A prevents the progression from prediabetes to diabetes through a multi-pathway intervention mechanism." 01/01/2018 - "Oroxin A is a compound with low toxicity that has reduced the relative risk of progression from prediabetes to diabetes by 66.7% without inducing weight gain or hepatotoxicity. " 01/01/2018 - "Oroxin A from Oroxylum indicum prevents the progression from prediabetes to diabetes in streptozotocin and high-fat diet induced mice."
2.	Breast Neoplasms (Breast Cancer) 03/01/2016 - "In this study, we found that oroxin A, an active component isolated from the herb Oroxylum indicum (L.) Kurz, effectively inhibited the growth of human breast cancer cells MDA-MB-231 and MCF7 by inducing endoplasmic reticulum (ER) stress-mediated senescence. " 03/01/2016 - "In addition, oroxin A increased cell population with high β-Gal activity and SAHF-positive staining; these data suggest that oroxin A induces breast cancer cell ER stress and senescence. " 03/01/2016 - "Oroxin A caused breast cancer cell cycle arrest at the G2/M stage, and reorganization of microtubules and actin cytoskeleton accompanied by a decrease in cellular mitosis. " 03/01/2016 - "Oroxin A inhibits breast cancer cell growth by inducing robust endoplasmic reticulum stress and senescence."
3.	Myocardial Ischemia (Ischemic Heart Diseases) 01/01/2022 - "Natural Compound Library Screening Identifies Oroxin A for the Treatment of Myocardial Ischemia/Reperfusion Injury."
4.	Weight Gain 01/01/2018 - "Oroxin A is a compound with low toxicity that has reduced the relative risk of progression from prediabetes to diabetes by 66.7% without inducing weight gain or hepatotoxicity. "
5.	Reperfusion Injury 01/01/2022 - "Natural Compound Library Screening Identifies Oroxin A for the Treatment of Myocardial Ischemia/Reperfusion Injury."

Related Drugs and Biologics

1.	Streptozocin (Streptozotocin)
2.	Endoplasmic Reticulum Chaperone BiP