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6- t- butyl- 2- (furan- 2- carboxamido)- 4,5,6,7- tetrahydrobenzo(b)thiophene- 3- carboxylic acid

a calcium-activated chloride channel inhibitor; structure in first source

Also Known As:

CaCC(inh)-A01; CaCCinh-A01

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - 6-t-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carboxylic acid: 10
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - 6-t-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo(b)thiophene-3-carboxylic acid: 10

Experts

1.	Hollywood, Mark A: 2 articles (11/2017 - 11/2017)
2.	Large, Roddy J: 2 articles (11/2017 - 11/2017)
3.	McHale, Noel G: 2 articles (11/2017 - 11/2017)
4.	Sergeant, Gerard P: 2 articles (11/2017 - 11/2017)
5.	Thornbury, Keith D: 2 articles (11/2017 - 11/2017)
6.	Chen, Xiao-Shan: 1 article (01/2022)
7.	Chen, Xing-Feng: 1 article (01/2022)
8.	Cheng, Li-Min: 1 article (01/2022)
9.	Du, Yan-Hua: 1 article (01/2022)
10.	Guan, Yong-Yuan: 1 article (01/2022)

Related Diseases

1.	Sexually Transmitted Diseases (Sexually Transmitted Disease) 11/01/2022 - "STICs reversed close to the predicted Cl- equilibrium potential and both STICs and STDs were blocked by the TMEM16A channel blockers, Ani9 and CaCC(inh)-A01. " 11/01/2017 - "Similarly, spontaneous transient inward currents (STICs) recorded from RUICC voltage clamped at -60 mV and spontaneous transient depolarizations (STDs), recorded in current clamp, were also inhibited by CACCinh-A01 and T16Ainh-A01. "
2.	Hyperalgesia 01/01/2023 - "CaCCinh-A01 reduces allodynia and restores bestrophin-1 expression. " 01/01/2023 - "CaCCinh-A01 reversed bestrophin-1 overexpression-induced tactile allodynia and restored bestrophin-1 expression. " 09/04/2014 - "Furthermore, niflumic acid and CaCCinh-A01 also prevented in a dose-dependent manner the long-lasting evoked secondary mechanical allodynia and hyperalgesia in the ipsilateral and contralateral paws. " 01/01/2023 - "Accordingly, intrathecal injection of the bestrophin-1 blocker CaCCinh-A01 (1-10 µg) reverted SNT- or SNL-induced tactile allodynia in a concentration-dependent manner. "
3.	Brain Infarction 01/01/2019 - "Caccinh-A01, an TMEM16A inhibitor that reduced its upregulation, attenuated brain infarct size and neurological deficits after ischemic stroke. "
4.	Neoplasms (Cancer) 08/01/2023 - "Human colon HT-29 cancer cells were treated with GlyH-101 or CaCCinh-A01 or GlyH-101 plus CaCCinh-A01 complex. " 08/01/2023 - "Available evidence suggests that GlyH-101 and CaCCinh-A01 can suppress cell proliferation, block invasion and metastasis, and cause several cancer cell types to undergo apoptosis, demonstrating their anti-tumor properties. "
5.	Neoplasm Metastasis (Metastasis) 08/01/2023 - "Available evidence suggests that GlyH-101 and CaCCinh-A01 can suppress cell proliferation, block invasion and metastasis, and cause several cancer cell types to undergo apoptosis, demonstrating their anti-tumor properties. "

Related Drugs and Biologics

1.	T16AInh-A01
2.	Proteins (Proteins, Gene)
3.	Chloride Channels (Chloride Channel)
4.	Niflumic Acid
5.	Fibronectins (Fibronectin)
6.	Dihydrotachysterol (AT 10)
7.	Collagen
8.	Bestrophins
9.	N- (2- naphthalenyl)- ((3,5- dibromo- 2,4- dihydroxyphenyl)methylene)glycine hydrazide

Related Therapies and Procedures

1.	Spinal Injections