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PZ-128 peptide

pepducin, Antiplatelet Agent for treatment of Coronary Artery Disease

Also Known As:

P1pal-7

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 114793
- Lipopeptides: 626
  - PZ-128 peptide: 2
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cell-Penetrating Peptides: 734
    - PZ-128 peptide: 2
  - Lipopeptides: 626
    - PZ-128 peptide: 2

Experts

1.	Agarwal, Anika: 2 articles (07/2011 - 08/2009)
2.	Covic, Lidija: 2 articles (07/2011 - 08/2009)
3.	Kuliopulos, Athan: 2 articles (07/2011 - 08/2009)
4.	Nguyen, Nga: 2 articles (07/2011 - 08/2009)
5.	O'Callaghan, Katie: 2 articles (07/2011 - 08/2009)
6.	Yang, Eric: 2 articles (07/2011 - 08/2009)
7.	Brinckerhoff, Larry: 1 article (07/2011)
8.	Cisowski, Jaroslaw: 1 article (07/2011)
9.	Deng, Qing: 1 article (07/2011)
10.	Fogel, Michael: 1 article (07/2011)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2009 - "Consistently, biochemical analysis of xenograft tumors treated with P1pal-7 or MMP-1 inhibitor showed attenuated Akt activity. " 07/01/2011 - "Comparable in efficacy with Bevacizumab, monotherapy with the PAR1 i3 loop pepducin P1pal-7 provided significant 75% inhibition of lung tumor growth in nude mice. " 08/01/2009 - "Ectopic expression of constitutively active Akt rescues breast cancer cells from the synergistic cytotoxicity of P1pal-7 and Taxotere, suggesting that Akt is a critical component of PAR1-dependent cancer cell viability. "
2.	Neoplasm Metastasis (Metastasis) 08/01/2009 - "Both a MMP-1 inhibitor and P1pal-7 significantly promote apoptosis in breast tumor xenografts and inhibit metastasis to the lungs by up to 88%. "
3.	Breast Neoplasms (Breast Cancer) 08/01/2009 - "Both a MMP-1 inhibitor and P1pal-7 significantly promote apoptosis in breast tumor xenografts and inhibit metastasis to the lungs by up to 88%. " 08/01/2009 - "This process is blocked by a cell-penetrating lipopeptide "pepducin," P1pal-7, which is a potent inhibitor of cell viability in breast carcinoma cells expressing PAR1. " 08/01/2009 - "Ectopic expression of constitutively active Akt rescues breast cancer cells from the synergistic cytotoxicity of P1pal-7 and Taxotere, suggesting that Akt is a critical component of PAR1-dependent cancer cell viability. "

Related Drugs and Biologics

1.	Bevacizumab (Avastin)
2.	Lipopeptides
3.	Docetaxel (Taxotere)