4- methyl- N- (3- (4- methylimidazol- 1- yl)- 5- trifluoromethylphenyl)- 3- (4- pyrazin- 2- ylpyrimidin- 2- ylamino)benzamide

01/01/2018 - "Determination of a radotinib dosage regimen based on dose-response relationships for the treatment of newly diagnosed patients with chronic myeloid leukemia."
09/01/2017 - "Radotinib and its clinical potential in chronic-phase chronic myeloid leukemia patients: an update."
01/01/2016 - "Optimization of radotinib doses for the treatment of Asian patients with chronic myelogenous leukemia based on dose-response relationship analyses."
01/01/2015 - "Radotinib in the treatment of chronic phase chronic myeloid leukemia patients."
01/01/2022 - "Therefore, there is urgent need to develop new treatment options for MM. Radotinib is a novel anti-cancer drug, currently approved in South Korea for the treatment of chronic myeloid leukemia patients. "

07/31/2023 - "According to the concept of drug repositioning, we investigated the efficacy of the c-Abl tyrosine kinase inhibitor radotinib, which is a drug that is approved for the treatment of chronic myeloid leukemia, in the treatment of disease progression in prion models, including prion-infected cell models, Tga20 and hamster cerebellar slice culture models, and 263K scrapie-infected hamster models. "

07/31/2023 - "Based on our findings, we suggest that radotinib is a new candidate anti-prion drug that could possibly be used to treat prion diseases and promote the remission of symptoms."
07/31/2023 - "Radotinib Decreases Prion Propagation and Prolongs Survival Times in Models of Prion Disease."

07/31/2023 - "Interestingly, hamsters that were intraperitoneally injected with the 263K scrapie strain and intragastrically treated with radotinib (100 mg/kg) exhibited prolonged survival times (159 ± 28.6 days) compared to nontreated hamsters (135 ± 9.9 days) as well as reduced PrPSc deposition and ameliorated pathology. "
07/31/2023 - "Radotinib inhibited PrPSc deposition in neuronal ZW13-2 cells that were infected with the 22L or 139A scrapie strains and in cerebellar slice cultures that were infected with the 22L or 263K scrapie strains. "
07/31/2023 - "According to the concept of drug repositioning, we investigated the efficacy of the c-Abl tyrosine kinase inhibitor radotinib, which is a drug that is approved for the treatment of chronic myeloid leukemia, in the treatment of disease progression in prion models, including prion-infected cell models, Tga20 and hamster cerebellar slice culture models, and 263K scrapie-infected hamster models. "

01/01/2022 - "In this study, we analyzed the effect of radotinib on multiple myeloma cells. "
01/01/2021 - "In this study, we analyzed the effect of radotinib on multiple myeloma cells. "
01/01/2022 - "However, little is known about the effects of radotinib on multiple myeloma cells. "
01/01/2022 - "However, little is known about the effects of radotinib on multiple myeloma cells. "
01/01/2022 - "Radotinib inhibits multiple myeloma cell proliferation via suppression of STAT3 signaling."