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PXS-4728A

an inhibitor of VAP-1 protein, which has semicarbazide-sensitive amine oxidase activity; structure in first source

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Yuh-Lien: 2 articles (01/2018 - 01/2018)
2.	Chuang, Lee-Ming: 2 articles (01/2018 - 01/2018)
3.	Hung, Chi-Sheng: 2 articles (01/2018 - 01/2018)
4.	Kao, Hsien-Li: 2 articles (01/2018 - 01/2018)
5.	Li, Hung-Yuan: 2 articles (01/2018 - 01/2018)
6.	Lin, Mao-Shin: 2 articles (01/2018 - 01/2018)
7.	Tsai, Feng-Chiao: 2 articles (01/2018 - 01/2018)
8.	Wang, Shu-Huei: 2 articles (01/2018 - 01/2018)
9.	Yu, Tse-Ya: 2 articles (01/2018 - 01/2018)
10.	Li, Yu-I: 1 article (01/2018)

Related Diseases

1.	Inflammation (Inflammations) 11/01/2016 - "Treatment with a low MW inhibitor of SSAO, PXS-4728A, suppressed airway inflammation and fibrosis and improved lung function in experimental COPD, demonstrating the therapeutic potential of PXS-4728A for this debilitating disease." 03/20/2015 - "These results highlight the potential of inhibiting of VAP-1/SSAO enzymatic function, by PXS-4728A, as a novel therapeutic approach in lung diseases that are characterized by neutrophilic pattern of inflammation." 03/20/2015 - "LPS inflammation, Klebsiella pneumoniae infection, cecal ligation and puncture as well as rhinovirus exacerbated asthma models were also assessed using PXS-4728A. "
2.	Fibrosis (Cirrhosis) 11/01/2016 - "Treatment with a low MW inhibitor of SSAO, PXS-4728A, suppressed airway inflammation and fibrosis and improved lung function in experimental COPD, demonstrating the therapeutic potential of PXS-4728A for this debilitating disease." 02/01/2016 - "Oral administration of a recently reported selective semicarbazide-sensitive amine oxidase inhibitor, PXS-4728A, for 1 week attenuated kidney injury and interstitial fibrosis compared with vehicle. "
3.	Chronic Obstructive Pulmonary Disease (COPD) 11/01/2016 - "The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model." 11/01/2016 - "Treatment with a low MW inhibitor of SSAO, PXS-4728A, suppressed airway inflammation and fibrosis and improved lung function in experimental COPD, demonstrating the therapeutic potential of PXS-4728A for this debilitating disease."
4.	Atherosclerotic Plaque (Atheroma) 01/01/2018 - "Treatment with PXS-4728A, a selective VAP-1/SSAO inhibitor, in cholesterol-fed rabbits significantly decreased SSAO-specific hydrogen peroxide generation in the aorta and reduced atherosclerotic plaques. "
5.	Atherosclerosis 01/01/2018 - "VAP-1/SSAO inhibition by PXS-4728A is a potential treatment for atherosclerosis." 01/01/2018 - "Here, we examined if plasma VAP-1/SSAO is a biomarker for CAD diagnosed by coronary angiography in humans and investigated the effect of VAP-1/SSAO inhibition by a specific inhibitor PXS-4728A on atherosclerosis in cell and animal models. "

Related Drugs and Biologics

1.	Amine Oxidase (Copper-Containing)
2.	human AOC3 protein
3.	Biomarkers (Surrogate Marker)
4.	Hydrogen Peroxide (Hydroperoxide)
5.	Cholesterol

Related Therapies and Procedures

1.	Punctures
2.	Ligation
3.	Oral Administration