HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

7- chloro- 5- (2- isopropylphenyl)- 3,5- dihydro- 4,1- benzothiazepin- 2- (1H)- one

ITH12575 is the (S)-isomer; CGP37157 refers to the compound without isomeric designation; a CALHM1 channel blocker; structure in first source

Also Known As:

CGP37157; ITH12575

Networked: 5 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiepins
    - Thiazepines: 6
      - 7-chloro-5-(2-isopropylphenyl)-3,5-dihydro-4,1-benzothiazepin-2-(1H)-one: 5
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azepines: 11
    - Thiazepines: 6
      - 7-chloro-5-(2-isopropylphenyl)-3,5-dihydro-4,1-benzothiazepin-2-(1H)-one: 5
  - Thiepins
    - Thiazepines: 6
      - 7-chloro-5-(2-isopropylphenyl)-3,5-dihydro-4,1-benzothiazepin-2-(1H)-one: 5

Experts

1.	Alvarez, Javier: 1 article (01/2021)
2.	Alvarez-Illera, Pilar: 1 article (01/2021)
3.	Cabello, Juan: 1 article (01/2021)
4.	Fonteriz, Rosalba I: 1 article (01/2021)
5.	García-Casas, Paloma: 1 article (01/2021)
6.	Gómez-Orte, Eva: 1 article (01/2021)
7.	Montero, Mayte: 1 article (01/2021)
8.	Froelich, Katrin: 1 article (09/2015)
9.	Ginzkey, Christian: 1 article (09/2015)
10.	Hackenberg, Stephan: 1 article (09/2015)

Related Diseases

1.	Sarcopenia 01/01/2021 - "Here we show that CGP37157 significantly improved the evolution with age of the sarcomeric regular structure, delaying development of sarcopenia in C. "
2.	Prostatic Neoplasms (Prostate Cancer) 05/01/2014 - "Mitofusin 1 degradation is induced by a disruptor of mitochondrial calcium homeostasis, CGP37157: a role in apoptosis in prostate cancer cells." 05/01/2014 - "Our previous study demonstrated that androgens increase the expression of a mitochondrial protein involved in fission and facilitate an apoptotic response to CGP37157 (CGP), an inhibitor of mitochondrial calcium efflux, in prostate cancer cells. "
3.	Central Nervous System Diseases (CNS Diseases) 08/01/2015 - "These results could serve as a starting point for the development of more selective CALHM1 ligands using CGP37157 as a hit compound, which would help to study the physiological role of CALHM1 in the control of [Ca(2+)]cyt in excitable cells, as well as its implication in CNS diseases. "
4.	Mitochondrial Diseases (Mitochondrial Disease) 04/10/2014 - "In summary, our results provide evidence that during excitotoxicity CGP37157 modulates cytosolic and mitochondrial Ca(2+) dynamics that leads to attenuation of NMDA-induced mitochondrial dysfunction and neuronal cell death by blocking VGCCs. "
5.	Squamous Cell Carcinoma of Head and Neck 09/01/2015 - "Effects of salinomycin and CGP37157 on head and neck squamous cell carcinoma cell lines in vitro."

Related Drugs and Biologics

1.	Mitochondrial Proteins (Mitochondrial Protein)
2.	Ligands
3.	Calcium
4.	Androgens
5.	N-Methylaspartate (NMDA)
6.	salinomycin