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(2- hydroxy- 5- methoxyphenyl)(9H- pyrido(2,3- b)indol- 3- yl)methanone

a microtubule depolymerizing agent and Top2 inhibitor with antineoplastic activity; structure in first source

Also Known As:

YCH337

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Carbolines: 283
      - (2-hydroxy-5-methoxyphenyl)(9H-pyrido(2,3-b)indol-3-yl)methanone: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        Carbolines: 283
        (2-hydroxy-5-methoxyphenyl)(9H-pyrido(2,3-b)indol-3-yl)methanone: 1
  - 3-Ring Heterocyclic Compounds
    - Carbolines: 283
      - (2-hydroxy-5-methoxyphenyl)(9H-pyrido(2,3-b)indol-3-yl)methanone: 1

Experts

1.	Chen, Yi: 1 article (04/2015)
2.	Ding, Jian: 1 article (04/2015)
3.	Huan, Xia-Juan: 1 article (04/2015)
4.	Miao, Ze-Hong: 1 article (04/2015)
5.	Song, Shan-Shan: 1 article (04/2015)
6.	Sun, Yi-Ming: 1 article (04/2015)
7.	Tian, Qian-Ting: 1 article (04/2015)
8.	Wang, Wei: 1 article (04/2015)
9.	Wang, Ying-Qing: 1 article (04/2015)
10.	Yang, Chun-Hao: 1 article (04/2015)

Related Diseases

1.

Neoplasms (Cancer)

04/20/2015 - "Importantly, YCH337 nearly equally killed different-mechanism-mediated resistant tumor cells and corresponding parent cells. "
04/20/2015 - "YCH337 inhibited proliferation of tumor cells with an averaged IC50 of 0.3 μM. "
04/20/2015 - "Together with the novelty of its chemical structure, YCH337 could serve as a promising lead for drug development and a prototype for a dual microtubule/Top2 targeting strategy for cancer therapy. "
04/20/2015 - "Here we report YCH337, a novel α-carboline derivative that targets both microtubule and Top2, eliciting tumor proliferation and growth inhibition and overcoming drug resistance. "
04/20/2015 - "Dual targeting of microtubule and topoisomerase II by α-carboline derivative YCH337 for tumor proliferation and growth inhibition."

Related Drugs and Biologics

1.	Type II DNA Topoisomerases (Topoisomerase II)
2.	Carbolines (Beta-Carbolines)

Related Therapies and Procedures

1.	Therapeutics