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PS121912

a vitamin D receptor-coregulator inhibitor with antineoplastic activity; structure in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - PS121912: 2
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - PS121912: 2

Experts

1.	Arnold, Leggy A: 2 articles (11/2015 - 10/2014)
2.	Bikle, Daniel D: 2 articles (11/2015 - 10/2014)
3.	Cook, James M: 2 articles (11/2015 - 10/2014)
4.	Guthrie, Margaret L: 2 articles (11/2015 - 10/2014)
5.	Han, Lanlan: 2 articles (11/2015 - 10/2014)
6.	Sidhu, Preetpal S: 2 articles (11/2015 - 10/2014)
7.	Silvaggi, Nicholas R: 2 articles (11/2015 - 10/2014)
8.	Singh, Rakesh K: 2 articles (11/2015 - 10/2014)
9.	Yuan, Nina Y: 2 articles (11/2015 - 10/2014)
10.	Hill, Emily K: 1 article (11/2015)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2014 - "In addition, PS121912 showed an acceptable metabolic stability to enable in vivo cancer studies." 10/01/2014 - "At sub-micromolar concentrations, PS121912 amplified the growth inhibition of cancer cells caused by 1,25-(OH)₂D₃ without being antiproliferative by itself. " 10/01/2014 - "PS121912 induced apoptosis in all four cancer cells, with HL-60 cells being the most sensitive. " 10/01/2014 - "Antiproliferation and apoptosis were determined using four different cancer cell lines (DU145, Caco2, HL-60 and SKOV3) in the presence of PS121912, 1,25-(OH)₂D₃, or a combination of 1,25-(OH)₂D₃ and PS121912. " 11/01/2015 - "31B reduced ovarian cancer xenograft tumor growth and PS121912 inhibited the growth of HL-60-derived xenografts without any sign of toxicity. "
2.	Ovarian Neoplasms (Ovarian Cancer) 11/01/2015 - "31B reduced ovarian cancer xenograft tumor growth and PS121912 inhibited the growth of HL-60-derived xenografts without any sign of toxicity. " 11/01/2015 - "To investigate the in vivo effects of 3-indolylmethanamines 31B and PS121912 in treating ovarian cancer and leukemia, respectively. "
3.	Leukemia 11/01/2015 - "To investigate the in vivo effects of 3-indolylmethanamines 31B and PS121912 in treating ovarian cancer and leukemia, respectively. "
4.	Hypercalcemia (Milk Alkali Syndrome) 10/01/2014 - "PS121912 has been developed as selective vitamin D receptor (VDR)-coregulator inhibitor starting from a high throughput screening campaign to identify new agents that modulate VDR without causing hypercalcemia. "

Related Drugs and Biologics

1.	Calcitriol Receptors (Calcitriol Receptor)