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gingerenone A

has antineoplastic activity; isolated from Zingiber officinale; structure in first source

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Diarylheptanoids: 471
        gingerenone A: 6
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Heptanes: 70
        Diarylheptanoids: 471
        gingerenone A: 6

Experts

1.	Lee, Ki Won: 2 articles (10/2017 - 09/2015)
2.	Thimmegowda, N R: 2 articles (10/2017 - 09/2015)
3.	Chang, Hsueh-Wei: 1 article (03/2022)
4.	Chen, Chung-Yi: 1 article (03/2022)
5.	Hou, Ming-Feng: 1 article (03/2022)
6.	Ou-Yang, Fu: 1 article (03/2022)
7.	Shiau, Jun-Ping: 1 article (03/2022)
8.	Tang, Jen-Yang: 1 article (03/2022)
9.	Yen, Chia-Hung: 1 article (03/2022)
10.	Yu, Tzu-Jung: 1 article (03/2022)

Related Diseases

1.	Obesity 10/01/2017 - "Our objectives here are to identify bioactive compounds that inhibit adipogenesis and lipid accumulation in vitro, elucidate the anti-obesity effect of gingerenone A (GA) in diet-induced obesity (DIO), and investigate whether GA affects adipose tissue inflammation (ATI). " 10/01/2017 - "Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice."
2.	Neoplasms (Cancer) 09/25/2015 - "The effect of gingerenone A was strongly associated with relative phosphorylation levels of JAK2 and S6K1, and administration of gingerenone A significantly suppressed tumor growth in vivo. " 09/25/2015 - "Through a direct comparison of various ginger compounds, we determined that gingerenone A selectively kills cancer cells while exhibiting minimal toxicity toward normal cells. " 09/25/2015 - "Kinase array screening revealed JAK2 and S6K1 as the molecular targets primarily responsible for gingerenone A-induced cancer cell death. "
3.	Insulin Resistance 12/01/2018 - "Gingerenone A (Gin A) has been identified as an inhibitor of p70 S6 (S6K1), a kinase that plays a critical role in the pathogenesis of insulin resistance. "
4.	Inflammation (Inflammations) 10/01/2017 - "Our objectives here are to identify bioactive compounds that inhibit adipogenesis and lipid accumulation in vitro, elucidate the anti-obesity effect of gingerenone A (GA) in diet-induced obesity (DIO), and investigate whether GA affects adipose tissue inflammation (ATI). " 10/01/2017 - "Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice."
5.	Colitis 10/05/2022 - "Gingerenone A Alleviates Ferroptosis in Secondary Liver Injury in Colitis Mice via Activating Nrf2-Gpx4 Signaling Pathway."

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5.	Lipids
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8.	nootkatone
9.	myricetin
10.	gamma-sitosterol (beta-sitosterol)