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1,11- O- o- methylbenzylidene- 7- O- p- cyanobenzoyl- 1,7,11- trideacetylpyripyropene A

a sterol O-acyltransferaser 2 inhibitor; structure in first source

Also Known As:

PRD125

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 1,11-O-o-methylbenzylidene-7-O-p-cyanobenzoyl-1,7,11-trideacetylpyripyropene A: 2
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - 1,11-O-o-methylbenzylidene-7-O-p-cyanobenzoyl-1,7,11-trideacetylpyripyropene A: 2

Experts

1.	Ohshiro, Taichi: 2 articles (11/2015 - 11/2015)
2.	Rudel, Lawrence L: 2 articles (11/2015 - 11/2015)
3.	Tomoda, Hiroshi: 2 articles (11/2015 - 11/2015)
4.	Chuang, Jen-Chieh: 1 article (11/2015)
5.	Davis, Matthew A: 1 article (11/2015)
6.	Ishibashi, Shun: 1 article (11/2015)
7.	Lopez, Adam M: 1 article (11/2015)
8.	Matsuda, Daisuke: 1 article (11/2015)
9.	Nagamitsu, Tohru: 1 article (11/2015)
10.	Ohtawa, Masaki: 1 article (11/2015)

Related Diseases

1.	Atherosclerosis 11/01/2015 - "These results suggest that SOAT2-selective inhibitors such as PRD125 have a high potential as poststatin agents for treatment and/or prevention in patients with atherosclerosis and hypercholesterolemia. "
2.	Hypercholesterolemia 11/01/2015 - "These results suggest that SOAT2-selective inhibitors such as PRD125 have a high potential as poststatin agents for treatment and/or prevention in patients with atherosclerosis and hypercholesterolemia. "
3.	Body Weight (Weight, Body) 11/01/2015 - "In Lal(-/-) males given the selective SOAT2 inhibitor PRD125 1,11-O-o-methylbenzylidene-7-O-p-cyanobenzoyl-1,7,11-trideacetylpyripyropene A in their diet (∼10 mg/day per kg body weight) from 21 to 53 days, whole liver cholesterol content was 48.6 versus 153.7 mg in untreated 53-day-old Lal(-/-) mice. "

Related Drugs and Biologics

1.	1,11- O- o- methylbenzylidene- 7- O- p- cyanobenzoyl- 1,7,11- trideacetylpyripyropene A
2.	Cholesterol
3.	poststatin