A-1262543

an adrenergic alpha2B receptor agonist; structure in first source

Also Known As:

N-(2-(pyridin-3-yl)-4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-imidazol-2-amine

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Pain (Aches) 05/01/2015 - "Duloxetine, but not A-1262543, also inhibited the firing of pain non-responsive (nPR) neurones in the mPFC probably reflecting duloxetine's contribution to modulating non-pain endpoints. " 05/01/2015 - "In contrast to the lack of effect on spinal neurones, both A-1262543 and duloxetine reduced the evoked and spontaneous firing of 'pain-responsive' (PR) neurones in the mPFC. "
2.	Hyperalgesia 05/01/2015 - "Systemic administration of A-1262543 (1-10 mg/kg, intraperitoneal) dose-dependently attenuated mechanical allodynia in animals with a spinal nerve ligation injury. "

1.	Duloxetine Hydrochloride (Cymbalta)

1.	Ligation