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1- acetyl- 2- docosahexaenoyl- glycerophosphocholine

has anti-atherothombotic activity; structure in first source

Also Known As:

AceDoPC

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Membrane Lipids: 1591
  - Phospholipids: 11903
    - Glycerophosphates: 118
      - Phosphatidic Acids: 358
        Glycerophospholipids: 689
        Phosphatidylcholines: 2371
        1-acetyl-2-docosahexaenoyl-glycerophosphocholine: 4

Experts

1.	Lagarde, Michel: 3 articles (08/2017 - 05/2011)
2.	Bernoud-Hubac, Nathalie: 2 articles (08/2017 - 01/2016)
3.	Guichardant, Michel: 2 articles (08/2017 - 05/2011)
4.	Picq, Madeleine: 2 articles (01/2016 - 05/2011)
5.	Fourrier, Célia: 1 article (08/2017)
6.	Greenhalgh, Andrew D: 1 article (08/2017)
7.	Joffre, Corinne: 1 article (08/2017)
8.	Layé, Sophie: 1 article (08/2017)
9.	Remus-Borel, Julie: 1 article (08/2017)
10.	Breton, Gildas: 1 article (01/2016)

Related Diseases

1.	Stroke (Strokes) 01/01/2015 - "In addition, AceDoPC prevents more efficiently the deleterious effects of the experimental stroke in rats than does unesterified DHA. " 05/01/2011 - "The present study used multimodal MRI to assess in vivo the neuroprotection conferred by DHA and by a brain-targeting form of DHA-containing lysophosphatidylcholine (AceDoPC) in experimental stroke. "
2.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 05/01/2011 - "Rats underwent intraluminal middle cerebral artery occlusion (MCAO) and were treated at reperfusion by intravenous injection of i) saline, ii) plasma from donor rats, iii) DHA or iv) AceDoPC, both solubilized in plasma. "
3.	Neuroinflammatory Diseases 08/24/2017 - "In this work, we analyzed the anti-inflammatory activity of DHA-phospholipid, either acetylated at the sn-1 position (AceDoPC, a stable form thought to have superior access to the brain) or acylated with palmitic acid at the sn-1 position (PC-DHA) using a lipopolysaccharide (LPS)-induced neuroinflammation model both in vitro and in vivo. "
4.	Ischemic Stroke 01/01/2016 - "We used a structured phosphatidylcholine to mimic 2-docosahexaenoyl-lysoPC (lysoPC-DHA), named AceDoPC (1-acetyl,2-docosahexaenoyl-glycerophosphocholine), that may be considered as a stabilized form of the physiological lysoPC-DHA and that is neuroprotective in experimental ischemic stroke. "

Related Drugs and Biologics

1.	Lysophosphatidylcholines (Lysophosphatidylcholine)
2.	Palmitic Acid (Hexadecanoic Acid)
3.	Phospholipids (Phosphatides)
4.	Phosphatidylcholines (Phosphatidylcholine)
5.	Lipopolysaccharides
6.	docosahexaenoyl lysophosphatidylcholine

Related Therapies and Procedures

1.	Intravenous Injections