gintonin

activates lysophosphatidic acid receptors; consists of lysophosphatidic acids, ginseng major latex-like protein, and ginseng ribonuclease-like storage proteins; isolated from Panax ginseng

Networked: 46 relevant articles (8 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nah, Seung-Yeol: 32 articles (05/2022 - 01/2012)
2.	Choi, Sun-Hye: 21 articles (05/2021 - 01/2012)
3.	Kim, Hyoung-Chun: 19 articles (05/2021 - 01/2012)
4.	Cho, Ik-Hyun: 15 articles (05/2021 - 09/2015)
5.	Kim, Hyeon-Joong: 15 articles (01/2020 - 01/2012)
6.	Rhim, Hyewhon: 14 articles (05/2021 - 12/2016)
7.	Lee, Byung-Hwan: 10 articles (01/2018 - 01/2012)
8.	Hwang, Sung-Hee: 9 articles (03/2020 - 01/2015)
9.	Cho, Hee-Jung: 8 articles (05/2021 - 02/2012)
10.	Choi, Jong Hee: 5 articles (05/2021 - 01/2018)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 01/01/2015 - "In in vivo studies, gintonin elicits anti-Alzheimer's disease activity through the activation of the non-amyloidogenic pathway and anti-metastatic effects through the inhibition of autotaxin. " 12/01/2016 - "However, little is known about whether gintonin can induce hippocampal cell proliferation in adult wild-type mice and an APPswe/PSEN-1 double Tg mouse model of Alzheimer's disease (AD). " 12/01/2016 - "Effects of gintonin-enriched fraction on hippocampal cell proliferation in wild-type mice and an APPswe/PSEN-1 double Tg mouse model of Alzheimer's disease." 10/01/2015 - "Gintonin-mediated [Ca(2+)]i transient is linked to anti-Alzheimer's activity in transgenic Alzheimer's disease animal model. " 01/01/2015 - "Gintonin has been widely studied for its anti-Alzheimer's disease activities and other neuropathies. "
2.	Parkinson Disease (Parkinson's Disease) 01/01/2019 - "It remains for future basic and clinical research to determine the potential use of gintonin in Parkinson's disease. " 01/01/2018 - "Multi-Target Protective Effects of Gintonin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Mediated Model of Parkinson's Disease via Lysophosphatidic Acid Receptors." 01/01/2019 - "In this study, we sought to investigate the potential protective mechanisms of gintonin in an in vivo MPTP and in vitro MPP+-mediated Parkinson's disease (PD) model. " 03/01/2021 - "Gintonin-enriched fraction (GEF) exhibits anti-brain senescence and effects against disorders such as Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease (PD). " 01/01/2020 - "Therefore, we collected the main scientific findings and comprehensively presented them, covering preparation, absorption, and receptor-mediated functions, including effects against Alzheimer's disease models, Parkinson's disease models, anxiety and depression-like models, and other neurological disorders, aiming to provide some insights for the possible usage of gintonin in the management of neurodegenerative conditions."
3.	Cognitive Dysfunction 01/01/2012 - "Gintonin also rescued Aβ1-40-induced cognitive dysfunction in mice. " 01/01/2021 - "Collectively, the findings of this preclinical study highlight and endorse the potential, multitargeted protective effects of gintonin against AD-associated oxidative damage, neuroinflammation, cognitive impairment, and neurodegeneration." 01/01/2020 - "We previously showed that gintonin exhibits diverse effects from neurotransmitter release to improvement of Alzheimer's disease-related cognitive dysfunctions. " 09/11/2018 - "Numerous preclinical studies have confirmed that ginseng and its active components such as ginsenosides, gintonin, and compound K are pharmacologically efficacious in different models of and are linked to cognitive impairment. "
4.	Amyloid Plaque 04/01/2021 - "Although β-amyloid plaque depositions in AD is accompanied with disruptions of brain microvessels, including the brain-blood barrier (BBB), it is unknown whether gintonin exerts protective effects on brain microvascular dysfunctions in AD Tg mice. " 01/01/2012 - "Moreover, in a transgenic mouse AD model, long-term oral administration of gintonin attenuated amyloid plaque deposition as well as short- and long-term memory impairment. " 10/01/2018 - "Oral administration of gintonin attenuates brain amyloid plaque deposits, boosting hippocampal cholinergic systems and neurogenesis, thereby ameliorating learning and memory impairments. " 04/01/2021 - "In the present study, the effects of gintonin-enriched fraction (GEF) on the changes in β-amyloid plaque depositions, brain permeability of Evans blue, and microvascular junctional proteins were investigated in AD Tg mice. " 12/01/2016 - "We previously showed that gintonin, an exogenous lysophosphatidic acid (LPA) receptor ligand, attenuated β-amyloid plaque formation in the cortex and hippocampus, and restored β-amyloid-induced memory dysfunction. "
5.	Neuroinflammatory Diseases 01/01/2021 - "Gintonin demonstrated neuroprotective activity by providing action against neuroinflammation-, apoptosis- and oxidative stress-mediated neurodegeneration. " 01/01/2021 - "Collectively, the findings of this preclinical study highlight and endorse the potential, multitargeted protective effects of gintonin against AD-associated oxidative damage, neuroinflammation, cognitive impairment, and neurodegeneration." 01/01/2019 - "We hypothesized that activation of nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1, potential therapeutic targets for neurodegeneration) with gintonin could abrogate PD-associated neurotoxicity by modulating the accumulation of α-synuclein, neuroinflammation, and apoptotic cell death in an MPTP/MPP+ models of PD. " 01/01/2021 - "is a well-known medicinal plant that contains ginsenosides, gintonin, and other components and has neuroprotective effects against a series of pathological cascades in AD, including beta-amyloid formation, neuroinflammation, oxidative stress, and mitochondrial dysfunction. "

Related Drugs and Biologics

1.	Amyloid beta-Peptides
2.	Peptide Hydrolases (Proteases)
3.	Lysophosphatidic Acid Receptors
4.	Curcumin
5.	pomiferin
6.	Ginsenosides
7.	Neuroprotective Agents
8.	Therapeutic Uses
9.	Proteins (Proteins, Gene)
10.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)

Related Therapies and Procedures

1.	Oral Administration