eicosanoyl-5-hydroxytryptamide

protects phosphoprotein phosphatase 2A from demethylation and inactivation; structure in first source

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

1.	Neuroinflammatory Diseases 01/01/2013 - "One of these compounds is eicosanoyl-5-hydroxytryptamide (EHT), which ameliorates the phenotype of α-synuclein transgenic mice associated with decreased protein aggregation and phosphorylation, improved neuronal integrity and reduced neuroinflammation. "
2.	Parkinson Disease (Parkinson's Disease) 01/01/2017 - "In addition, eicosanoyl-5-hydroxytryptamide (EHT), a naturally occurring component from coffee beans that modulates PP2A methylation, was shown to confer therapeutic benefits in rodent models of AD and Parkinson's disease. " 12/18/2018 - "Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB."
3.	Alzheimer Disease (Alzheimer's Disease) 01/01/2017 - "Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid." 12/01/2014 - "A minor component of coffee unrelated to caffeine, eicosanoyl-5-hydroxytryptamide (EHT), provides protection in a rat model for Alzheimer's disease (AD). "