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VER-246608

inhibits pyruvate dehydrogenase kinase; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bae, Sung-Jin: 1 article (11/2021)
2.	Cho, Minkyoung: 1 article (11/2021)
3.	Ha, Ki-Tae: 1 article (11/2021)
4.	Han, Jung Ho: 1 article (11/2021)
5.	Jin, Ling: 1 article (11/2021)
6.	Kim, Bo-Sung: 1 article (11/2021)
7.	Kim, Jae Ho: 1 article (11/2021)
8.	Lee, In-Kyu: 1 article (11/2021)
9.	Park, Sungmi: 1 article (11/2021)
10.	Ryu, Dongryeol: 1 article (11/2021)

Related Diseases

1.

Neoplasms (Cancer)

11/01/2021 - "Leelamine, huzhangoside A and otobaphenol induced PDH activity-dependent apoptosis, whereas AZD7545, VER-246608 and DCA effectively enhanced PDHA1 activity but little toxic to cancer cells. "
12/30/2014 - "VER-246608 was weakly anti-proliferative to cancer cells in standard culture media; however, depletion of either serum or combined D-glucose/L-glutamine resulted in enhanced cellular potency. "
12/30/2014 - "VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells."

Related Drugs and Biologics

1.	Protein Isoforms (Isoforms)
2.	Glutamine (L-Glutamine)
3.	Glucose (Dextrose)
4.	Culture Media
5.	Adenosine Triphosphate (ATP)
6.	Pyruvate Dehydrogenase Acetyl-Transferring Kinase
7.	AZD 7545
8.	dehydroabietylamine