SAR127303

inhibits monoacylglycerol lipase; structure in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Neuroinflammatory Diseases 01/01/2021 - "PET studies of the brains of the ischemic rats were performed at several experimental time points (pre-occlusion, days 2, 4, and 7 after the MCAO surgery) using [11C]SAR127303 for MAGL and [18F]FEBMP for 18 kDa translocator protein (TSPO, a hall-mark of neuroinflammation). "
2.	Visceral Pain 01/06/2015 - "In vivo, SAR127303 produces antinociceptive effects in assays of inflammatory and visceral pain. "
3.	Seizures (Absence Seizure) 01/06/2015 - "Although inactive in acute seizure tests, repeated administration of SAR127303 delays the acquisition and decreases kindled seizures in mice, indicating that the drug slows down epileptogenesis, a finding deserving further investigation to evaluate the potential of MAGL inhibitors as antiepileptics. "

1.	Proteins (Proteins, Gene)
2.	Anticonvulsants (Antiepileptic Drugs)