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aspidin PB

has both anti-fibrotic and antineoplastic activities; isolated from Dryopteris fragrans; structure in first source

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Cyclohexanones: 5
    - aspidin PB: 6
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Phloroglucinol: 132
        aspidin PB: 6
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        Cyclohexanones: 5
        aspidin PB: 6

Experts

1.	Gao, Chang: 2 articles (03/2016 - 01/2013)
2.	Luo, Meng: 2 articles (03/2016 - 01/2013)
3.	Wang, Wei: 2 articles (03/2016 - 01/2013)
4.	Fu, Yu-Jie: 1 article (03/2016)
5.	Guo, Na: 1 article (03/2016)
6.	Li, Na: 1 article (03/2016)
7.	Peng, Xiao: 1 article (03/2016)
8.	Wang, Peng: 1 article (03/2016)
9.	Chai, Yimin: 1 article (10/2015)
10.	Hua, Xin: 1 article (10/2015)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 01/25/2013 - "In the present study, we analyzed the apoptotic mechanisms of aspidin PB on human hepatoma cell line, HepG2. "
2.	Neoplasms (Cancer) 10/01/2015 - "In addition, aspidin PB inhibited tumor growth significantly in U2OS xenografts. " 08/01/2000 - "Amongst the isolates, aspidin PB (8), dryofragin (9), and 1-5 exhibited potent ichthyotoxic activity against medaka with a median tolerance limit (TLm after 24 h) of 1.2-4.3 microg/ml. These compounds which are toxic to fish also had a potent inhibitory effect on the activation of Epstein-Barr virus early-antigen (EBV-EA) induced by tetradecanoyl phorbol 13-acetate, which is an in vitro short-term assay for anti-tumor promoting agents. " 04/01/2014 - "Phytochemicals in the class of flavonoids (apigenin, quercetin, isoliquiritigenin, and 2'-hydroxyflavanone), isoflavonoids (formononetin and genistein), catechins (epigallocatechin gallate and epicatechin gallate), stilbenoids (resveratrol and pinosylvin), phenolics (6-gingerol), phloroglucinols (rottlerin and aspidin PB), terpenoids (18 α-glycyrrhetinic acid, platycodin D, pseudolaric acid B, and xanthorrhizol), alkaloids (berberine, capsaicin, and indole-3-carbinol), lignans (isochaihulactone), anthraquinones (damnacanthal), and allyl sulfides (diallyl disulfide) elicited NAG-1 overexpression in various cancer cells. "
3.	Osteosarcoma (Osteogenic Sarcoma) 10/01/2015 - "We reported that aspidin PB induced cell cycle arrest and apoptosis through the p53/p21 and mitochondria-dependent pathways in human osteosarcoma cells. " 10/01/2015 - "Cell cycle arrest and apoptosis induced by aspidin PB through the p53/p21 and mitochondria-dependent pathways in human osteosarcoma cells." 10/01/2015 - "Above all, we conclude that aspidin PB represents a valuable natural source and may potentially be applicable in osteosarcoma therapy. "
4.	Keloid 08/05/2015 - "Our findings imply that aspidin PB has a therapeutic potential to intervene and prevent keloids and other fibrotic diseases. " 08/05/2015 - "The effect of aspidin PB on cell viability in human keloid fibroblasts was measured by MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide). " 08/05/2015 - "Aspidin PB, a novel natural anti-fibrotic compound, inhibited fibrogenesis in TGF-β1-stimulated keloid fibroblasts via PI-3K/Akt and Smad signaling pathways."
5.	Acne Vulgaris 03/01/2016 - "fragrans (L.) Schott to treat acne might be phloroglucinol derivatives including aspidin BB, aspidin PB, aspidinol and dryofragin. "

Related Drugs and Biologics

1.	Phytochemicals
2.	Apigenin
3.	Genistein
4.	Lignans
5.	Terpenes (Terpenoids)
6.	Sulfides (Thioethers)
7.	Stilbenes
8.	Quercetin
9.	Phloroglucinol
10.	Glycyrrhetinic Acid (Po 12)

Related Therapies and Procedures

1.	Therapeutics