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3- (3,5- dimethoxyphenyl)- 1- (2- methoxyphenyl)prop- 2- en- 1- one

has antineoplastic activity; structure in first source

Also Known As:

(E)-3-(3,5-dimethoxyphenyl)-1-(2-methoxyphenyl)prop-2-en-1-one; DPP-23 compound; DPP23

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lee, Young Han: 3 articles (11/2020 - 09/2016)
2.	Shin, Soon Young: 3 articles (11/2020 - 09/2016)
3.	Jung, Euitaek: 2 articles (11/2020 - 02/2020)
4.	Lim, Yoongho: 2 articles (02/2020 - 09/2016)
5.	Choi, Ji Hye: 1 article (11/2020)
6.	Lee, Da Hyun: 1 article (11/2020)
7.	Sim, Hongnam: 1 article (11/2020)
8.	Koh, Dongsoo: 1 article (02/2020)
9.	Jang, Hyejin: 1 article (11/2016)
10.	Kim, Eun Hye: 1 article (11/2016)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 09/23/2016 - "In the present study, we evaluated the effect of DPP23 on tumour invasion and metastasis. " 09/23/2016 - "Collectively, these results suggest that DPP23 could be used as a potential platform for the prevention of invasion and metastasis of early-stage breast cancer or as an adjuvant for chemo/radiotherapy." 09/23/2016 - "In addition, DPP23 attenuated experimental liver metastasis in a syngenic intrasplenic transplantation model using 4T1 mouse mammary carcinoma cells. "
2.	Neoplasms (Cancer) 02/01/2020 - "DPP23 can be used as a target pharmacophore for the development of novel chemotherapeutic agents capable of overcoming drug resistance in cancer cells, particularly ovarian cancer cells. " 11/01/2016 - "A novel synthetic polyphenol conjugate, (E)-3-(3,5-dimethoxyphenyl)-1-(2-methoxyphenyl)prop-2-en-1-one (DPP-23), selectively kills tumor cells via the reactive oxygen species (ROS)-mediated unfolded protein response. " 11/01/2020 - "The synthetic chalcone derivative (E)-3-(3,5-dimethoxyphenyl)-1-(2-methoxyphenyl)prop-2-en-1-one (DPP23) exerts antitumor activity through ROS-mediated apoptosis in cancer cells but not in healthy cells. " 09/23/2016 - "(E)-3-(3,5-dimethoxyphenyl)-1-(2-methoxyphenyl)prop-2-en-1-one (DPP23) is a synthetic polyphenol derivative that selectively induces apoptosis in cancer cells through the unfolded protein response pathway. "
3.	Pancreatic Neoplasms (Pancreatic Cancer) 11/01/2020 - "Multiple genes were up and downregulated by DPP23 treatment in MiaPaCa2 pancreatic cancer cells. " 11/01/2020 - "Transcriptomic analysis of the effect of (E)-3-(3,5-dimethoxyphenyl)-1-(2-methoxyphenyl) prop-2-en-1-one (DPP23) on reactive oxygen species generation in MIA PaCa-2 pancreatic cancer cells."
4.	Ovarian Neoplasms (Ovarian Cancer) 02/01/2020 - "DPP23 can be used as a target pharmacophore for the development of novel chemotherapeutic agents capable of overcoming drug resistance in cancer cells, particularly ovarian cancer cells. " 02/01/2020 - "We found that DPP23 triggered apoptosis in both parental cisplatinsensitive A2780 and cisplatin-resistant A2780/CisR ovarian cancer cells due to activation of reactive oxygen species (ROS)-mediated unfolded protein response (UPR) pathway in the endoplasmic reticulum. "
5.	Necrosis 09/23/2016 - "Here, we show that DPP23 inhibited tumour necrosis factor alpha (TNFα)-induced motility, F-actin formation, and the invasive capability of MDA-MB-231 cells. "

Related Drugs and Biologics

1.	3- (3,5- dimethoxyphenyl)- 1- (2- methoxyphenyl)prop- 2- en- 1- one
2.	Reactive Oxygen Species (Oxygen Radicals)
3.	Polyphenols
4.	Cisplatin (Platino)
5.	Chalcone (Benzalacetophenone)
6.	Actins (F Actin)

Related Therapies and Procedures

1.	Transplantation
2.	Radiotherapy