metuzumab

01/01/2015 - "Mice bearing human tumor xenografts were used to evaluate the antitumor efficacy of metuzumab. "
01/01/2017 - "Taken together, the mechanisms of metuzumab combined with GP repress tumor growth were that the combined treatment significantly inhibited the tumor cell proliferation, apoptosis and cell cycle in vitro and in vivo and at least partially by induction of dCK expression. "
01/01/2017 - "Our results demonstrate that, in comparison to single agent metuzumab or GP treated cells, metuzumab combined with GP display inhibitory effects on tumor growth. "
01/01/2017 - "We have previously shown that metuzumab inhibit tumor growth in vivo. "
01/01/2015 - "Metuzumab also effectively inhibited tumor growth in A549 and NCI-H520 xenograft models. "

01/01/2019 - "Subcutaneous xenograft nude mouse model was used to investigate the antitumor efficacy of Metuzumab against esophageal cancer in vivo. "
01/01/2019 - "Methods: ADCC assay was used to explore the antitumor efficacy of Metuzumab against esophageal cancer in vitro. "
01/01/2019 - "Metuzumab inhibited migration and invasion of esophageal cancer through blockade of CD147 in vitro. "
01/01/2019 - "Wound healing assay and Boyden Chamber invasion assay were performed to explore whether Metuzumab could inhibit migration and invasion of esophageal cancer in vitro. "
01/01/2019 - "Conclusions: The in vitro and in vivo study demonstrated dual effects of Metuzumab in effectively mediating ADCC by activating effector cells, and inhibiting metastasis of esophageal cancer through blockade the function of CD147, providing justification for moving Metuzumab forward to clinical development in esophageal cancer."

01/01/2019 - "Conclusions: The in vitro and in vivo study demonstrated dual effects of Metuzumab in effectively mediating ADCC by activating effector cells, and inhibiting metastasis of esophageal cancer through blockade the function of CD147, providing justification for moving Metuzumab forward to clinical development in esophageal cancer."

01/01/2017 - "Metuzumab enhanced chemosensitivity and apoptosis in non-small cell lung carcinoma."
01/01/2015 - "These preclinical safety data facilitated the initiation of an ongoing clinical trial of metuzumab for the treatment of non-small cell lung cancer (NSCLC) in China."

01/01/2019 - "Experiments in vivo showed that Metuzumab exhibited significant antitumor efficacy and inhibited lymph node metastasis of esophageal cancer in xenograft models. "
01/01/2019 - "The esophageal cancer tissue microarrays (TMA) was examined for identification of association of CD147 with lymph node metastasis, and the footpad xenograft nude mouse model was used to explore whether Metuzumab could inhibit lymph node metastasis of esophageal cancer in vivo. "