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SL25.1188

a radiotracer for monoamine oxidase B; structure in first source

Also Known As:

5-(methoxymethyl)-3-(6-(4,4,4-trifluorobutoxy)benzo(d)isoxazol-3-yl)oxazolidin-2-one

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Isoxazoles: 155
      - SL25.1188: 3
    - Oxazoles: 89
      - Oxazolidinones: 316
        SL25.1188: 3

Experts

1.	Meyer, Jeffrey H: 3 articles (01/2022 - 01/2019)
2.	Houle, Sylvain: 2 articles (01/2022 - 01/2019)
3.	Kish, Stephen J: 2 articles (01/2022 - 01/2019)
4.	Vasdev, Neil: 2 articles (01/2022 - 01/2019)
5.	Boileau, Isabelle: 1 article (01/2022)
6.	Gill, Talwinder: 1 article (01/2022)
7.	Hutchison, Michael G: 1 article (01/2022)
8.	Jetly, Rakesh: 1 article (01/2022)
9.	McCluskey, Tina: 1 article (01/2022)
10.	Rhind, Shawn G: 1 article (01/2022)

Related Diseases

1.	Major Depressive Disorder (Major Depressive Disorders) 01/01/2022 - "[11C]SL25.1188 availability was ∼30% lower in corticolimbic regions in PTSD with co-morbid major depressive disorder (MDD) (n = 4) vs HC (p = 0.001) and vs PTSD without MDD (p = 0.005). " 01/01/2019 - "Monoamine Oxidase B Total Distribution Volume in the Prefrontal Cortex of Major Depressive Disorder: An [11C]SL25.1188 Positron Emission Tomography Study." 01/01/2021 - "[11C]SL25.1188 PET was applied to discover a substantive elevation of MAO-B binding in the prefrontal cortex in major depressive disorder (MDD) with an effect size of more than 1.5. "
2.	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/01/2022 - "PTSD was associated with a trending reduction in [11C]SL25.1188 availability across regions (8-17%; p = 0.067) implicating the ventral striatum (p uncorrected = 0.015) and medial prefrontal cortex (p uncorrected = 0.060). " 01/01/2022 - "[11C]SL25.1188 availability was ∼30% lower in corticolimbic regions in PTSD with co-morbid major depressive disorder (MDD) (n = 4) vs HC (p = 0.001) and vs PTSD without MDD (p = 0.005). " 01/01/2022 - "Imaging of astrocytes in posttraumatic stress disorder: A PET study with the monoamine oxidase B radioligand [11C]SL25.1188." 01/01/2022 - "MAO-B availability ([11C]SL25.1188 distribution volume) was measured in 13 participants with PTSD (∼39 years, 6F) and 17 healthy controls (HC) (∼31 years, 9F). " 01/01/2022 - "We used positron emission tomography (PET) of the monoamine oxidase (MAO)-B probe [11C]SL25.1188 to test the hypothesis that levels of MAO-B, an index of astrocyte levels is decreased in PTSD. "
3.	Gliosis 01/01/2021 - "Given the number of diseases with elevations of MAO-B density and astrogliosis, and the advance of [11C]SL25.1188, clinical applications of MAO-B imaging are still at an early stage."

Related Drugs and Biologics

1.	Monoamine Oxidase (MAO)