(4- (2- chlorophenyl- 4- fluoro- 1- piperidinyl)(5- (1H- pyrazol- 4- yl)- 3- thienyl)methanone

inhibits 11beta-hydroxysteroid dehydrogenase type 1

Also Known As:

UE2316

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - (4-(2-chlorophenyl-4-fluoro-1-piperidinyl)(5-(1H-pyrazol-4-yl)-3-thienyl)methanone: 4
  - Thiophenes: 257
    - (4-(2-chlorophenyl-4-fluoro-1-piperidinyl)(5-(1H-pyrazol-4-yl)-3-thienyl)methanone: 4
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - (4-(2-chlorophenyl-4-fluoro-1-piperidinyl)(5-(1H-pyrazol-4-yl)-3-thienyl)methanone: 4

Experts

1.	Walker, Brian R: 4 articles (01/2018 - 03/2014)
2.	Webster, Scott P: 4 articles (01/2018 - 03/2014)
3.	Seckl, Jonathan R: 3 articles (12/2015 - 03/2014)
4.	Yau, Joyce L W: 2 articles (12/2015 - 04/2015)
5.	Aucott, Rebecca L: 1 article (01/2018)
6.	Chapman, Karen E: 1 article (01/2018)
7.	Dora, Elena: 1 article (01/2018)
8.	Forbes, Stuart J: 1 article (01/2018)
9.	Henderson, Neil C: 1 article (01/2018)
10.	Iredale, John P: 1 article (01/2018)

Related Diseases

1.	Cognitive Dysfunction 12/01/2015 - "Chronic treatment of young Tg2576 mice with UE2316 for up to 13 months prevented cognitive decline but did not prevent Aβ plaque formation. "
2.	Uremia 03/11/2014 - "Furthermore, 11βHSD1(-/-) mice and rats treated with a specific 11βHSD1 inhibitor (UE2316) were protected from metabolic disturbances despite similar renal dysfunction following adenine experimental uremia. "
3.	Shock 04/01/2015 - "When the order of treatment was reversed following extinction of the original fear memory, and a second foot-shock conditioning was given in a novel context, UE2316 treated aged mice (previously on vehicle) now showed increased fear memory compared to vehicle-treated aged mice (previously on UE2316). " 04/01/2015 - "In contrast, contextual fear memory induced by foot-shock conditioning was significantly reduced by UE2316 in a non-reversible manner. "
4.	Fibrosis (Cirrhosis) 01/01/2018 - "In vivo [4-(2-chlorophenyl-4-fluoro-1-piperidinyl][5-(1H-pyrazol-4-yl)-3-thienyl]-methanone administration prior to chemical injury recapitulated findings in Hsd11b1-/- mice, including greater fibrosis. "
5.	Alzheimer Disease (Alzheimer's Disease) 12/01/2015 - "In the Tg2576 mouse model of Alzheimer's disease, UE2316 treatment of mice aged 14 months for 4 weeks also decreased the number of β-amyloid (Aβ) plaques in the cerebral cortex, associated with a selective increase in local insulin-degrading enzyme (involved in Aβ breakdown and known to be glucocorticoid regulated). "

Related Drugs and Biologics

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