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ESK246

synthetic antineoplastic; structure in first source

Also Known As:

venuloside A

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bailey, Charles G: 1 article (06/2014)
2.	Bonham, Sarah: 1 article (06/2014)
3.	Font, Josep: 1 article (06/2014)
4.	Grkovic, Tanja: 1 article (06/2014)
5.	Holst, Jeff: 1 article (06/2014)
6.	Jormakka, Mika: 1 article (06/2014)
7.	Moran, Anne M: 1 article (06/2014)
8.	Pouwer, Rebecca H: 1 article (06/2014)
9.	Quinn, Ronald J: 1 article (06/2014)
10.	Rasko, John E J: 1 article (06/2014)

Related Diseases

1.	Neoplasms (Cancer) 06/20/2014 - "Our study suggests that ESK246 is a LAT3 inhibitor that can be used to study LAT3 function and upon which new antiprostate cancer therapies may be based."
2.	Prostatic Neoplasms (Prostate Cancer) 06/20/2014 - "We further show in LNCaP prostate cancer cells that ESK246 is a potent (IC50 = 8.12 μM) inhibitor of leucine uptake, leading to reduced mTORC1 signaling, cell cycle protein expression and cell proliferation. " 06/20/2014 - "Monoterpene glycoside ESK246 from Pittosporum targets LAT3 amino acid transport and prostate cancer cell growth."

Related Drugs and Biologics

1.	Monoterpenes (Monoterpenoids)
2.	Proteins (Proteins, Gene)
3.	Leucine (L-Leucine)
4.	Glycosides
5.	Amino Acids
6.	Mechanistic Target of Rapamycin Complex 1

Related Therapies and Procedures

1.	Therapeutics