AS2521780

inhibits protein kinase C theta; structure in first source

Also Known As:

4-(((4-(((4-hydroxycyclohexyl)methyl)amino)adamantan-1-yl)methyl)amino)-2-(((2-(methylsulfanyl)pyridin-3-yl)methyl)amino)pyrimidine-5-carbonitrile

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Inflammation (Inflammations) 12/15/2014 - "Here, we evaluated the effect of the novel PKCθ inhibitor AS2521780 on T cell activation and joint inflammation in a rat model of arthritis. "
2.	Autoimmune Diseases (Autoimmune Disease) 12/15/2014 - "These results indicate that PKCθ is an attractive drug target and AS2521780 is a potential immunosuppressant for T cell-mediated autoimmune diseases."
3.	Arthritis (Polyarthritis) 12/15/2014 - "Moreover, AS2521780 significantly reduced paw swelling in a dose-dependent manner in a rat model of adjuvant-induced arthritis. " 12/15/2014 - "Here, we evaluated the effect of the novel PKCθ inhibitor AS2521780 on T cell activation and joint inflammation in a rat model of arthritis. "

1.	Immunosuppressive Agents (Immunosuppressants)