methyl 3,4-dihydroxybenzoate

extends the lifespan of Caenorhabditis elegans, partly via W06A7.4 gene

Also Known As:

MDHB compound

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Hydroxybenzoates: 18
        methyl 3,4-dihydroxybenzoate: 6
        Benzoates: 426
        Hydroxybenzoates: 18
        methyl 3,4-dihydroxybenzoate: 6
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Hydroxybenzoates: 18
      - methyl 3,4-dihydroxybenzoate: 6
  - Carbocyclic Acids
    - Benzoates: 426
      - Hydroxybenzoates: 18
        methyl 3,4-dihydroxybenzoate: 6

Experts

1.	Gao, Qin: 2 articles (02/2020 - 08/2016)
2.	Luo, Huan Min: 2 articles (02/2020 - 04/2019)
3.	Mi, Xiang Nan: 2 articles (02/2020 - 04/2019)
4.	Pan, Jun Ping: 2 articles (02/2020 - 04/2019)
5.	Su, Ji Yan: 2 articles (02/2020 - 04/2019)
6.	Wang, Jia Hui: 2 articles (02/2020 - 04/2019)
7.	Cai, Liang: 2 articles (04/2019 - 08/2016)
8.	Zhang, Wei: 2 articles (04/2019 - 08/2016)
9.	Chen, Ke Qi: 1 article (02/2020)
10.	Hu, Yang: 1 article (02/2020)

Related Diseases

1.	Neuroblastoma 08/22/2016 - "This study investigated the neuroprotective effects of methyl 3,4-dihydroxybenzoate (MDHB) against t-butyl hydroperoxide (TBHP) induced oxidative damage in SH-SY5Y (human neuroblastoma cells) and the underlying mechanisms. "
2.	Neurodegenerative Diseases (Neurodegenerative Disease) 02/01/2020 - "Methyl 3,4-dihydroxybenzoate (MDHB) has the potential to prevent neurodegenerative diseases (NDDs). " 04/01/2019 - "Methyl 3,4-dihydroxybenzoate (MDHB) has the potential to prevent neurodegenerative diseases (NDDs). " 02/01/2020 - "Excretion, Metabolism and Cytochrome P450 Inhibition of Methyl 3,4-Dihydroxybenzoate (MDHB): A Potential Candidate to Treat Neurodegenerative Diseases."
3.	Acute Liver Failure (Fulminant Hepatic Failure) 07/01/2019 - "Methyl 3,4-dihydroxybenzoate can effectively resist d-galN/LPS-induced acute liver failure, which is related to the inhibition of inflammation and apoptosis." 07/01/2019 - "Aimed to investigate the effect and mechanism of methyl 3,4-dihydroxybenzoate (MDHB) on d-galactosamine/lipopolysaccharide (d-galN/LPS)-induced acute liver failure (ALF). "
4.	Osteoporosis 08/25/2022 - "Methyl 3,4-dihydroxybenzoate inhibits RANKL-induced osteoclastogenesis via Nrf2 signaling in vitro and suppresses LPS-induced osteolysis and ovariectomy-induced osteoporosis in vivo."
5.	Osteolysis 08/25/2022 - "Methyl 3,4-dihydroxybenzoate inhibits RANKL-induced osteoclastogenesis via Nrf2 signaling in vitro and suppresses LPS-induced osteolysis and ovariectomy-induced osteoporosis in vivo."

Related Drugs and Biologics

1.	tert-Butylhydroperoxide
2.	Neuroprotective Agents
3.	Lipopolysaccharides
4.	Galactosamine
5.	Cytochrome P-450 Enzyme System (Cytochrome P450)

Related Therapies and Procedures

1.	Ovariectomy (Oophorectomy)