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3- (4- chlorophenyl)- N- (7- hydroxy- 6- methoxy- 2- oxo- 2H- chromen- 3- yl)acrylamide

has antineoplastic activity; structure in first source

Also Known As:

SC-III3

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Li: 2 articles (07/2015 - 12/2014)
2.	Dai, Yue: 2 articles (07/2015 - 12/2014)
3.	Zhao, Peng: 2 articles (07/2015 - 12/2014)
4.	Dou, Yannong: 1 article (07/2015)
5.	Li, Linhu: 1 article (07/2015)
6.	Wei, Zhifeng: 1 article (07/2015)
7.	Wu, Xin: 1 article (07/2015)
8.	Xia, Yufeng: 1 article (07/2015)
9.	Yu, Juntao: 1 article (07/2015)
10.	Jia, Yu-Gai: 1 article (12/2014)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 12/19/2014 - "SC-III3 is able to efficiently inhibit the growth of hepatocellular carcinoma through inducing the generation of intracellular ROS, DNA damage and consequent S phase arrest, but lack of significant cytotoxicity against normal liver cells. " 12/19/2014 - "Human hepatocellular carcinoma cell line HepG2 cells and xenograft of HepG2 cells in BALB/c nude mice were used to investigate the effects of SC-III3 on hepatocellular cancers. " 07/01/2015 - "SC-III3, a novel scopoletin derivative, induces autophagy of human hepatoma HepG2 cells through AMPK/mTOR signaling pathway by acting on mitochondria."
2.	Mitochondrial Diseases (Mitochondrial Disease) 07/01/2015 - "Collectively, SC-III3 leads to autophagy through inducing mitochondrial dysfunction, depleting ATP, and activating AMPK-mTOR pathway, which thus reflects the cytotoxic effect of SC-III3 in HepG2 cells. "
3.	Neoplasms (Cancer) 12/19/2014 - "In mouse xenograft model of HepG2 cells, SC-III3 showed a marked inhibition of tumor growth in a dose-dependent manner. "
4.	Liver Neoplasms (Liver Cancer) 12/19/2014 - "Human hepatocellular carcinoma cell line HepG2 cells and xenograft of HepG2 cells in BALB/c nude mice were used to investigate the effects of SC-III3 on hepatocellular cancers. " 12/19/2014 - "SC-III3, a novel scopoletin derivative, induces cytotoxicity in hepatocellular cancer cells through oxidative DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation."
5.	Ataxia Telangiectasia (Louis Bar Syndrome) 12/19/2014 - "SC-III3, a novel scopoletin derivative, induces cytotoxicity in hepatocellular cancer cells through oxidative DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation."

Related Drugs and Biologics

1.	Scopoletin
2.	Phosphotransferases (Kinase)
3.	Nuclear Proteins (Protein, Nuclear)
4.	Adenosine Triphosphate (ATP)