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acetyl- aspartyl- glutamyl- valyl- aspartyl- chloromethyl ketone

a caspase inhibitor

Also Known As:

Ac-DEVD-cmk; AcDEVD-cmk; acetyl-Asp-Glu-Val-Asp-cmk

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Amino Acid Chloromethyl Ketones
    - acetyl-aspartyl-glutamyl-valyl-aspartyl-chloromethyl ketone: 3

Experts

1.	Avalos-Díaz, Esperanza: 1 article (03/2011)
2.	Herrera-Esparza, Rafael: 1 article (03/2011)
3.	López-Luna, Argelia: 1 article (03/2011)
4.	Pacheco-Tovar, Deyanira: 1 article (03/2011)
5.	Diaz, Luis A: 1 article (01/2009)
6.	Li, Ning: 1 article (01/2009)
7.	Liu, Zhi: 1 article (01/2009)
8.	Wang, Jinzhao: 1 article (01/2009)
9.	Zhao, Minglang: 1 article (01/2009)
10.	Panichakul, Tasanee: 1 article (09/2002)

Related Diseases

1.	Blister (Bulla) 03/02/2011 - "The main results of the present investigation are as follows: (1) pemphigus IgG induces intraepidermal blisters in Balb/c neonatal mice; (2) keratinocytes around the blister and acantholytic cells undergo apoptosis; (3) the caspases inhibitor Ac-DEVD-CMK prevents apoptosis; (4) the inhibition of the caspase pathway prevents blister formation. " 01/01/2009 - "Administration of Ac-DEVD-cmk, a peptide-based caspase-3/7 inhibitor, protected mice from developing intraepidermal blisters and clinical disease induced by PF IgG. The same protective effect was also observed using a broad-spectrum caspase inhibitor, Bok-D-fmk. "
2.	Cholangiocarcinoma 09/01/2002 - "The cleavage of PARP was inhibited when the cells were pretreated with the enzyme inhibitor AC-DEVD-CMK, suggesting that apoptosis induced by the combination of TNF-alpha and triptolide involved activation of caspase 3. These results indicate that apoptosis of human cholangiocarcinoma cell lines as induced by a combination of TNF-alpha and triptolide is mediated through caspase 3 activation."
3.	Pemphigus (Pemphigus Vulgaris) 03/02/2011 - "Using this strategy, we attempted to block the pathogenic effect of pemphigus IgG in Balb/c mice by using the caspase inhibitor Ac-DEVD-CMK. " 03/02/2011 - "The main results of the present investigation are as follows: (1) pemphigus IgG induces intraepidermal blisters in Balb/c neonatal mice; (2) keratinocytes around the blister and acantholytic cells undergo apoptosis; (3) the caspases inhibitor Ac-DEVD-CMK prevents apoptosis; (4) the inhibition of the caspase pathway prevents blister formation. "

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	Caspases
3.	Immunoglobulin G (IgG)
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Peptides (Polypeptides)
6.	Enzyme Inhibitors (Inhibitors, Enzyme)
7.	triptolide